Pharmaceutical Research Scientist - DMPK
Listed on 2026-09-27
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Research/Development
Pharmaceutical Science/ Research, Research Scientist, Drug Discovery -
Pharmaceutical
Pharmaceutical Science/ Research, Drug Discovery
About the Role
Our client is seeking a highly skilled Pharmaceutical Research Scientist specializing in Drug Metabolism and Pharmacokinetics (DMPK) to join their dynamic R&D team in Welkom . This role is integral to the drug discovery and development process, focusing on understanding how drugs are absorbed, distributed, metabolized, and excreted (ADME) by the body. You will conduct critical studies to evaluate the pharmacokinetic profiles of drug candidates, informing critical decisions about lead optimization and candidate selection.
The successful applicant will contribute to advancing our client's pipeline of innovative therapeutics within a collaborative and scientifically rigorous environment, ensuring the development of safe and effective medicines.
- Design and execute in vitro and in vivo studies to assess the ADME properties of drug candidates.
- Utilize bioanalytical techniques (e.g., LC-MS/MS) to quantify drug and metabolite concentrations in biological matrices.
- Analyze and interpret DMPK data to build pharmacokinetic models and predict human dose.
- Collaborate with medicinal chemistry, pharmacology, and toxicology teams to guide drug discovery efforts.
- Contribute to the preparation of regulatory documents related to DMPK data.
- Stay abreast of the latest scientific literature and technological advancements in DMPK.
- Ph.D. or Master's degree in Pharmacology, Pharmaceutical Sciences, Biochemistry, or a related field.
- Minimum of 3 years of experience in DMPK research within the pharmaceutical or biotechnology industry.
- Proficiency in bioanalytical method development and validation using LC-MS/MS.
- Strong understanding of pharmacokinetic principles and modeling software (e.g., Phoenix Win Nonlin).
- Experience with in vitro ADME assays (e.g., metabolic stability, Caco-2 permeability, CYP inhibition/induction).
- Excellent scientific communication and data presentation skills.
- Competitive salary and bonus potential.
- Comprehensive medical, dental, and vision insurance.
- Opportunities for scientific advancement and career growth.
- Access to state-of-the-art research facilities and equipment.
- A collaborative and stimulating research environment.
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