Sr. Manager, Accounts Payable

Sr. Manager, Accounts Payable

Alnylam Pharmaceuticals is seeking a Senior Manager, Accounts Payable to lead key aspects of our global, multi-entity Procure-to-Pay operations. Reporting to the Global Process Owner, P2P, this role ensures timely, accurate, and well-controlled Accounts Payable processes while advancing automation, process improvements, and strong customer service. The ideal candidate brings AP operational expertise, a process-focused mindset, and a collaborative approach to strengthening controls and enhancing the end-to-end P2P experience.

As a people leader, the role emphasizes clear communication, thoughtful development, and building team capability while fostering a supportive and accountable environment. This position partners widely across Finance and the business and contributes to ongoing P2P transformation and technology initiatives. This is a hybrid position and will be primarily based in Cambridge, MA.

Responsibilities:

• Lead and develop the AP team to deliver high-quality, timely, and accurate processing across global entities.
• Oversee daily Invoice to Pay activities, including invoice validation, exception resolution, vendor payments, and AP service request management.
• Monitor performance through KPIs and analytics to identify trends and drive improvements in efficiency, transparency, and service delivery.
• Partner with technical teams to enhance tools, expand automation, and support ERP or P2P-related system initiatives.
• Maintain strong internal controls and support SOX, fraud, and risk-mitigation activities.
• Partner closely with Procurement and other P2P stakeholders to align processes and support consistent policy application.
• Collaborate with Accounting, IT, Treasury, Audit, Operations, and Legal to support smooth end-to-end business operations.
• Manage AP month-end activities, including accruals, reconciliations, and vendor aging reviews.
• Provide clear communications and updates to stakeholders on operations, process recommendations, and improvement efforts.
• Support the scalability and continuous improvement of AP processes as the business grows.
• Ensure compliance with AP policies, accounting standards, and regulatory requirements such as 1099 reporting.

Qualifications:

• Bachelor's degree in accounting, finance, business, or related field, or equivalent experience.
• 7+ years of relevant experience, including 3+ years leading a global or geographically dispersed AP team.
• Strong understanding of end-to-end P2P processes and multi-entity AP operations.
• Demonstrated experience using automation, analytics, and process improvement to enhance AP efficiency and controls.
• Experience with enterprise financial systems and tools (SAP S/4
  
  HANA, Ariba, Open Text VIM preferred).
• Strong communication and relationship-building skills with both internal and external stakeholders.
• Experience supporting SOX, fraud mitigation, or other control-related activities within AP.
• Ability to manage multiple priorities in a fast-paced environment while maintaining accuracy and service levels.
• Background supporting or contributing to vendor master data processes is an advantage.
• Ability to support scalable processes as AP volumes and global operations expand.

U.S. Pay Range $ - $

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being.