Senior Manager, Forecasting & Analytics

Why Sarepta? Why Now?

The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.

We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.

At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:

• Physical and Emotional Wellness
• Financial Wellness
• Support for Caregivers

For a full list of our comprehensive benefits, see our website:

The Senior Manager, Forecasting and Analytics reports to the Director, Forecasting and Launch Readiness and is responsible for building robust commercial forecasts, generating decision-ready analyses, and developing perspectives that support the commercial success of Sarepta’s in-line and pipeline portfolio. This role partners closely with cross-functional stakeholders, including Competitive Intelligence, Market Research, Sales, Finance, Business Performance, Market Access, Patient Services, and International Business, to develop pressure-tested forecasts, commercial perspectives, and business targets.

• Build, own, and maintain lifecycle-appropriate forecasting models for Sarepta’s U.S. and global in-line and pipeline portfolio.
• Develop forecast scenarios, sensitivity analyses, business opportunity estimates, and near- and long-term therapy adoption projections.
• Translate strategic, operational, and financial drivers into robust forecast assumptions and models.
• Evolve forecasting capabilities through model refreshes, scenario analyses, and variance reporting in partnership with key stakeholders.
• Support planning processes, including S&OP, LRP, and LEs, ensuring risks and uncertainties are reflected in commercial decisions.
• Support quarterly HCP targeting activity for four in-market products to support demand generation and sales execution.
• Lead development and management of forecast models for pipeline therapies, including SiRNA programs.
• Drive ad hoc analyses to refine assumptions and support board and leadership discussions.
• Produce periodic demand forecasts in collaboration with Commercial, Finance, and Tech Ops.
• Monitor market dynamics and update forecasts to reflect relevant industry and therapeutic-area developments.
• Build strong cross-functional relationships with key collaborators.
• Perform other related duties as needed.

• Bachelor’s degree with 7-9 years of experience in a scientific, quantitative, or statistics-related field required; master’s degree with 5-7 years of experience strongly preferred.
• 5+ years of forecasting and analytics experience in biopharma; rare disease experience preferred; consulting experience a plus.
• Excellent communication skills, with the ability to distill insights and forecast perspectives for Commercial Leadership, Executive Committee, and Board discussions.
• Experience using AI tools and agents to automate recurring analyses and support deeper insight generation.
• Strong analytical mindset with solid quantitative skills.
• Advanced proficiency in Excel, Tableau, or similar data visualization and analysis tools.
• Preferred experience with advanced analysis using SQL, Python, or similar languages.
• Exceptional attention to detail.
• Strong logical and critical thinking skills, including the ability to perform quick, reliable back-of-the-envelope analyses for leadership discussions.
• Strong project management skills, with the ability…