Prologue Medicines, Inc Cambridge, MA Vice President, Biology and Translational Science

Vice President, Biology and Translational Science

Cambridge, MA USA

Prologue Medicines uses advances in structural predictions and large language models to functionally annotate the entire viral proteome to leverage millennia of viral evolution for the development of transformative medicines. Prologue has nominated two development candidates and is building a broad pipeline of therapeutics across several therapeutic areas. One of Prologue Medicines’ founding principles is to build an inclusive and exciting working environment that fosters personal and professional growth by ensuring that all team members contribute to and feel ownership of our scientific vision.

We are seeking an exceptional scientific leader to serve as VP/SVP, Biology & Translational Science, responsible for driving our discovery and early development strategy from target identification through IND and continue to support the program as needed through clinical development. This individual will integrate deep expertise in immunology, translational science and/or protein biologics to build a high‑impact pipeline and ensure successful progression of programs into the clinic.

The ideal candidate will have a proven ability to develop effective strategies and execution plans to advance early molecules through preclinical development to ensure emerging assets exhibit strong differentiation and a high possibility of success. They should have an excellent understanding of the landscape of immune‑mediated diseases to help build a diversified pipeline.

• Define translational strategies to bridge preclinical findings to human studies
• Lead identification and implementation of biomarkers (PD, predictive, and safety)
• Ensure programs are designed with clinical endpoints and patient stratification in mind
• Increase probability of clinical success through mechanism‑based approaches.
• In collaboration with PKPD/QSP modeling team, develop translational frameworks for AI‑enabled derisking of drug development path

• Lead progression of protein biologics programs from hit identification through lead optimization and IND‑enabling studies
• Partner cross‑functionally with discovery and development teams to build out and drive comprehensive IND strategy, including pharmacology, safety, and translational packages
• Ensure clear go/no‑go decision frameworks across discovery and preclinical stages
• Proactively recognize and develop creative solutions for emerging technical and scientific issues

• Lead target identification, evaluation, and nomination grounded in human biology and disease relevance
• Define and drive biological hypotheses aligned with company strategy, with a focus on immunology
• Oversee development of robust in vitro and in vivo models to validate targets and mechanisms
• Build and prioritize a portfolio strategy for multiple differentiated biologics programs

• Build, mentor and lead high‑performing teams delivering across biology, pharmacology, and translational science. Identify, initiate, and manage productive collaborations with CROs, partners and academic labs as appropriate to driving projects forward and collaborate closely with clinical development, regulatory, and executive leadership
• Develop, motivate and inspire a high‑performing Biology and Translational Science organization
• Serve as an enterprise leader, driving cross‑functional alignment, clear decision‑making, and a culture of accountability, innovation, and executional excellence.
• Serve as a key scientific voice with board members, investors, and external partners
• Foster a culture of rigor, innovation, collaborative and decisive execution

• PhD or MD/PhD in pharmacology or biological disciplines such as immunology, cellular biology, oncology, or biochemistry, with 10+ years direct pharmaceutical experience beyond postdoctoral work
• Deep expertise in immunology with a strong understanding of disease biology
• Proven track record advancing protein biologics from hit identification to IND
• Significant…