NPI​/Industrialization Engineer

Position: Staff NPI / Industrialization Engineer
About Portal Instruments Portal Instruments is redefining how advanced injectable therapies are delivered. Founded on MIT research, we are building a next-generation drug delivery platform that enables high- volume, high-viscosity biologics to move from IV infusion to subcutaneous injection, unlocking a new generation of at-home therapies. Our lead platform, PRIME Nexus™, combines reusable hardware with software-tunable delivery to enable therapies that were previously not feasible outside the clinic.

We have secured development partnerships with leading biotech companies and are now entering the most critical phase of the company: scaling from advanced engineering to clinical-ready and manufacturable systems Role Information

Title:

Staff NPI / Industrialization Engineer

Reports to:

VP, Engineering

Location:

Boston/Cambridge, MA (on-site presence required)

Position Overview This role is a critical part of Portal’s mission to advance PRIME Nexus® toward commercialization. You will work cross-functionally with engineering, quality, regulatory, manufacturing, and external partners to ensure that Portal’s designs translate into scalable, manufacturable products. Embedded within the engineering team, this role brings manufacturing, industrialization, and assembly into considerations into the design process from the earliest stage.

As Staff NPI Engineer you will design, build, test, and improve mechanical and electromechanical devices, equipment, and systems made by Portal Instruments for manufacturing and assembly. You will also design and build test and assembly fixtures for use in verification and manufacturing assemblies of drug delivery systems. You will partner closely with design engineering and the Head of Industrialization to ensure that what is designed can be built, scaled, and delivered reliably.

The goal of your work will be to eliminate late-stage surprises and accelerate the path to clinical and commercial readiness. This role is critical to eliminating the traditional “design-to-manufacturing gap” and enabling a tightly integrated development and industrialization process. T.  

E.  190 Fifth Street, Cambridge, MA 02141 What You’ll Do Your Role in our Operating Model
• Embedded within engineering, reporting to VP Engineering
• Partners closely with Industrialization / Manufacturing leadership
• Responsible for integrating manufacturability, assembly, and test considerations into product design
• Acts as a bridge between design engineering and manufacturing execution
• Provides early validation of design decisions against manufacturing and scalability constraints Your Impact
• Contribute directly to the development, validation, and commercialization of Portal’s drug-delivery platforms
• Collaborate across disciplines to solve complex technical and operational challenges
• Help ensure solutions are scalable, compliant, and grounded in real-world use

Key Responsibilities
• Drive early integration of DFM/DFA principles into product design, in partnership with engineering
• Evaluate and challenge designs for manufacturability, scalability, and assembly efficiency
• Identify and mitigate manufacturing risks early in development
• Collaborate with industrialization and external manufacturing partners (e.g., CDMOs) to ensure design feasibility
• Support design transfer by validating build readiness and resolving manufacturability gaps
• Partner with industrialization and manufacturing teams to ensure designs are ready for transfer and scalable production
• Design, develop, maintain, and verify mechanical components and assemblies for Portal’s drug delivery systems to medical device standards as necessary
• Produce rigorous documentation: including CAD & 2D design specifications, tolerance analysis, verification test plans, project schedules and change orders associated with Portal devices Be involved in the mechanical aspects for design verification and validation activities, as well as data collection and documentation for submission to regulatory agencies
• Design, build, and debug experimental test instrumentation
• Design and implement test methods for analysis and characterization of…