Director​/Senior Director Finance

Metaphore Biotechnologies, Inc. is a privately held biotechnology company building the next generation of biological therapeutics. Inspired by nature, our mission is to transform patient lives by unlocking the power of biological therapeutics with a new mimic-discovery platform.

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at  .

We are seeking a hands-on, detail-oriented Director/Senior Director Finance with strong financial planning and analysis capabilities to own the accounting and finance function. Reporting to the CFO, you will be the finance lead responsible for the accuracy, integrity, and scalability of each company's financial operations, going beyond the close to own budgeting, forecasting, and cash runway planning until each organization is large enough to separate those functions.

This is an individual contributor role best suited to someone who has thrived in early-stage environments, is comfortable being resourceful without a large team behind them, and finds genuine satisfaction in doing meaningful work across a range of financial disciplines.

• Own the end-to-end monthly close process, ensuring GAAP compliance and timely, accurate reporting in alignment with each company's established close calendar.
• Manage core accounting functions including general ledger, accounts payable, vendor payments, payroll, equity administration, and treasury across all entities in scope.
• Track and reconcile monthly expenses across each company, maintaining clean and current visibility into spend by department, program, and vendor.
• Identify transactions requiring specialized accounting treatment, including clinical trial accruals, collaboration revenue, equity compensation, and complex financing structures, and implement appropriate accounting, engaging external advisors as needed.
• Develop, implement, and maintain accounting policies and procedures that reflect each company's current stage while building toward public company readiness.

• Build and maintain the annual operating budget, working closely with functional leads to translate scientific and operational plans into financial models.
• Own cash runway forecasting across the portfolio, maintaining current, scenario-based projections that give leadership and investors clear visibility into each company's financial position and decision-making horizon.
• Produce clear, accurate monthly financial reports for each leadership team and Board, translating accounting outputs into meaningful business insights and variance commentary.
• Support rolling forecasts, program-level spend tracking, and ad hoc financial analyses that inform key decisions across the portfolio.
• Support CFO in developing long-range financial plans and scenario analyses for financing decisions.
• Partner with scientific leadership to translate research plans into resource and cash requirements.
• Evaluate hiring plans, capital investments, and external collaborations from a financial perspective.
• Support fundraising activities, including investor diligence materials and financial modeling.
• Build KPI dashboards for management and Boards.

• Design and implement…