Senior Medical Director, AATD

Job title: Senior Medical Director, AATD

Location: Cambridge, MA

Travel: Up to 25% travel expected

Join the team transforming care for people with immune challenges, rare diseases, cancers, and neurological conditions. In Specialty Care, you’ll help deliver breakthrough treatments that bring hope to patients with some of the highest unmet needs.

Sanofi's US Rare Medical Team is seeking an exceptional Senior Medical Director to serve as the foremost internal medical expert for Alpha-1 Antitrypsin Deficiency (AATD). This senior-level, strategic medical affairs role offers the opportunity to shape and lead the AATD medical strategy, drive scientific excellence, and contribute to breakthrough therapies that address the significant unmet medical needs of the AATD community.

The successful candidate will create a US medical plan, provide authoritative scientific leadership across the AATD landscape, mentor and develop field-based medical talent, and collaborate with cross-functional teams to advance Sanofi's AATD portfolio from late-stage development through commercialization.

We're an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

• Develop, own, and execute the comprehensive medical strategy for AATD, ensuring alignment with global medical affairs objectives and Sanofi's rare disease mission
• Serve as the primary internal medical authority and scientific resource for AATD, providing expert guidance to senior leadership and cross-functional stakeholders
• Provide scientific and clinical expertise to support AATD product lifecycle management from late-stage development through commercialization
• Lead medical input into strategic planning, including evidence generation, data gap analyses, post hoc analyses, and long-range medical planning for AATD
• Collaborate with global medical team to communicate and align on strategic imperatives
• Provide strategic direction, mentorship, and day-to-day guidance to the Field Science Director for AATD, supporting their professional development and ensuring field medical activities are aligned with the overarching AATD medical strategy
• Translate complex AATD disease biology and clinical data into actionable medical insights that inform portfolio decisions

• Collaborate with clinical development teams to provide AATD-specific medical insights for ongoing and future clinical trials
• Review and provide medical input on clinical protocols, study designs, and regulatory submissions relevant to AATD
• Support post-marketing surveillance activities and real-world evidence generation in the AATD patient population
• Contribute to risk management and pharmacovigilance activities, with particular attention to the AATD disease context

• Identify, develop, and maintain strategic relationships with leading AATD experts, pulmonologists and key opinion leaders across the US in other key specialties (Allergy/Immunology, Internal Medicine)
• Design and implement strategic digital initiatives to expand educational reach into community setting
• Plan and execute advisory boards, expert panels, and scientific meetings focused on AATD
• Facilitate scientific exchange and collaboration with external researchers, clinicians, and patient advocacy organizations in the AATD community
• Represent Sanofi at AATD-relevant scientific conferences, medical…