Compensation Manager; Contractor

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).

Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.

We are seeking a Contract Compensation Manager to support Amylyx through a period of growth. In this role, you will work closely with Talent Acquisition and the Total Rewards team to benchmark roles, evaluate job descriptions, and ensure competitive, equitable, and consistent offers. This is a unique opportunity to apply deep compensation expertise in a fast-paced environment where high-quality decision-making directly impacts our ability to attract top talent and support the communities we serve.

This role is ideal for someone who thrives in a fast‑paced environment, enjoys analytical problem‑solving, and partners seamlessly with Talent Acquisition to ensure consistent, high‑quality offer outcomes.

Core Focus Areas

• Partner closely with hiring managers and Talent Acquisition to benchmark new and evolving roles, validate leveling, and ensure job descriptions align with internal frameworks and external market data
• Provide compensation insights to TA and hiring managers, helping shape hiring strategies for new or hard‑to‑fill roles
• Advise TA on offer negotiation strategies to ensure consistency, fairness, and timely closings
• Partner with HR colleagues to align new roles to our leveling framework and ensure consistency across functions
• Support offer development, ensuring all offers reflect our compensation philosophy, internal equity, and compliance with pay standards
• Conduct market pricing using Radford and other survey data; prepare clear, well‑supported recommendations
• Maintain internal equity across teams and functions, analyzing trends, compression risks, and leveling consistency

Operational & Analytical Support

• Build and maintain Excel-based analytical tools to support fast, accurate offer modeling.
• Perform ad-hoc compensation analyses to support business decisions, including pay ranges, job mapping, and compensation health metrics
• Maintain a library of market data, benchmarks, and survey inputs to support hiring needs.
• Enhance existing tools, templates, and job benchmarking resources to enable TA to work more efficiently
• Develop quick‑reference guides or job‑matching tools to speed up pricing and leveling

Cross‑Functional Collaboration

• Serve as a subject matter expert on compensation practices for TA, HRBPs, and business leaders.
• Advise on compensation process improvements, including opportunities to streamline offer workflows, enhance data quality, and improve stakeholder experience.
• Contribute to broader Total Rewards and HR projects as needed

• 6+ years of compensation experience in biotech, pharma, high-growth tech or similar dynamic environments
• Preference for candidates with experience in pre‑commercial biotech, ideally with exposure to scaling compensation practices in advance of commercial launch
• Prior experience with Radford/AON and other relevant market surveys
• Exceptional analytical skills and expert‑level Excel proficiency.
• Strong attention to detail, with a commitment to producing accurate and thorough, market‑aligned analyses
• Ability to manage sensitive information with the highest level of confidentiality
• Highly resourceful, organized, and comfortable working in a fast‑paced, ambiguous environment
• Strong communication skills with the ability to translate complex data into clear guidance for non‑comp stakeholders
• Experience with equity…