Senior Project Manager, Program & Portfolio Management

Overview

Arbor Biotechnologies™, a next-generation gene editing company based in Cambridge, MA, is advancing a pipeline of novel gene editing therapeutics to address a wide range of genetic conditions – from the ultra-rare to the most common genetic diseases. The company’s unique suite of optimized gene editors goes beyond the limitations of early editing technologies to unlock access to new gene targets and has fueled a robust pipeline of first-in-class assets focused on diseases of high unmet need.

With Arbor’s lead program, ABO-101 for the treatment of primary hyperoxaluria type 1, progressing into clinical trials, the company continues to focus their research and development efforts on genomic diseases of the liver and CNS for which there are no existing functional cures. For more information, please visit: arbor.bio.

Who are you? Passionate, determined, and accountable. Curious, resourceful, innovative, forward thinking, and resilient. Authentic, humble, open-minded and puts team above self. At Arbor, our people embrace these qualities, so if this sounds like you then please read on!

We are seeking a highly motivated Project Manager/Senior Project Manager to drive cross-functional program execution while delivering strategic, data-driven insights that shape portfolio and investment decisions. This is a hybrid role for someone who thrives at the intersection of science, business, and operations
—combining rigorous project management fundamentals with analytical capabilities such as forecasting, scenario modeling, competitive intelligence, and strategic evaluation. You will play a critical role in translating breakthrough science into development-ready programs and ensuring that teams operate with clarity, alignment, and forward momentum.

This position sits at the center of Arbor’s innovation engine.

• Ensure our scientific teams have the structure, alignment, and visibility needed to deliver on high priority R&D milestones.
• Provide leadership with actionable insights that drive portfolio decisions and resource allocation.
• Help build and mature Arbor’s project and portfolio management discipline as the company scales.

Your work will directly accelerate program progress and influence how Arbor invests in its most promising scientific opportunities.

• Lead planning, execution, and tracking for cross-functional R&D programs, partnering with Research, Development, CMC, Regulatory, Clinical, and other stakeholders.
• Build, own, and maintain integrated program plans, timelines, dependencies, and risk registers.
• Orchestrate core team meetings, governance discussions, and executive updates—providing clarity, surfacing issues early, and enabling timely decisions.
• Proactively identify risks, resource constraints, and trade-offs; recommend mitigation strategies informed by scenario and sensitivity analysis.
• Ensure program objectives remain aligned with broader portfolio strategy and corporate priorities.

• Develop and maintain forecasting models for timelines, resources, milestones, probability-adjusted scenarios, and decision paths.
• Conduct competitive intelligence (CI) and landscape monitoring; integrate internal and external insights into program and portfolio recommendations.
• Create dashboards, analyses, and materials that provide leadership with clear, data-driven decision support.
• Partner with program leads and leadership to evaluate program prioritization, investment cases, and strategic options.

• Serve as a translator between scientific teams and business leadership - distilling complex concepts into clear plans, insights, and narratives.
• Drive consistency in project management tools, templates, and processes; contribute to maturing our PMO and portfolio capabilities.
• Enable a culture of transparency, accountability, and cross-functional collaboration.

• MBA, MS, or equivalent advanced training providing strong analytical and/or financial modeling foundations.
• Bachelor’s degree in a scientific discipline (e.g., biology,…