FL| Cambridge, MA; Senior Scientist, Cryo-EM Data Processing & Computational Workflows

(Senior) Scientist, Cryo-EM Data Processing & Computational Workflows

Cambridge, MA USA

Flagship Labs 109, Inc. (FL109) is a privately held, early-stage technology company pioneering the use of artificial intelligence, physics and hardware to transform the way we see biology. FL109 was conceived by Flagship Pioneering, which brings the courage, long-term vision, and resources needed to realize unreasonable results. Become part of our mission-driven team and help envision the future of science.

We are seeking a Cryo-EM Scientist to independently execute cryo-EM data processing across multiple programs. This role is responsible for delivering high-quality structural insights end-to-end and requires deep hands-on experience with cryo-EM data processing platforms, a strong practical understanding of single-particle cryo-EM, comfort operating within established internal software environments, and the ability to communicate results clearly in collaborative and client-facing settings.

• Independently process single-particle cryo-EM datasets from raw movies through validated reconstructions
• Build, refine and help interpret atomic models
• Apply, adapt, and troubleshoot established processing workflows
• Learn and efficiently use internally developed software tools and processing pipelines as a primary user
• Identify data-quality and processing-related issues and clearly distinguish them from infrastructure or software issues, engaging platform or engineering teams as needed
• Interpret results in the context of sample quality, data collection conditions, and experimental limitations, and communicate implications clearly
• Present results to internal stakeholders and external clients, fielding technical questions and defending conclusions in real time
• Collaborate with experimental, computational, and software teams to align on next steps across programs

• Demonstrated ability to independently process cryo-EM data using RELION or cryoSPARC
• Experience building and refining atomic models in Phenix, Coot, Chimera
  
  X/Isolde, etc.
• Sound practical understanding of single-particle cryo-EM, including common failure modes and tradeoffs related to sample quality (e.g., heterogeneity, preferred orientation, ice quality, particle behavior) and how these factors affect processing strategies and results
• Ability to explain complex technical concepts clearly to both scientific and non-specialist audiences
• Comfort onboarding into and operating within existing software tools and workflows without owning their development
• Demonstrated experience presenting technical or scientific work and the ability to clearly articulate results, assumptions, and technical tradeoffs in discussions with clients, collaborators, and software partners
• Strong working knowledge of UNIX/Linux environments and large-scale data handling
• Experience with scripting and light debugging in support of cryo-EM data analysis
• Experience using insights from cryo-EM data at multiple resolutions: complex formation, antibody mapping, high-resolution, etc.
• Experience working with diverse project/sample types

• Cryo-EM grid preparation and vitrification
• Cryo-EM microscope operation or data acquisition

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in generation of over 500 patents, initiation of over 50 clinical trials for novel therapeutic agents and an aggregate value of more than $90 billion.

Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social…