Scientist, -Throughput Biology Research

Position: Scientist, High-Throughput Biology United States + 1 more Research
## Scientist, High-Throughput Biology United States Apply Now Find out how well you match with this jobJob ID3166

This role is considered:

On-Site
** Overview
* * We are seeking a highly motivated scientist to join our High Throughput In Vitro Screening team. This role will lead the in vitro screening workflow to generate high-quality, decision-enabling data across multiple programs. This is a hands-on, in-lab role. The candidate is expected to contribute at the bench, partnering with associates and scientists to execute and troubleshoot experiments.

This position is
** onsite
* * and will be primarily located in Cambridge, MA.  
** Key Responsibilities
*** Lead, mentor, and develop scientists to foster a high-performing, collaborative team
* Drive end-to-end in vitro screening workflows, from assay development through data delivery, to enable timely, data-driven lead selection
* Design, optimize, and execute high-throughput assays (e.g., transfection, free uptake, qPCR/Taq Man, reporter assays) across diverse cell types
* Partner with automation and engineering teams to expand and optimize automated workflows, improving throughput, robustness, and operational efficiency
* Set and maintain high standards for data quality and reproducibility using assay metrics, controls, and QC frameworks
* Identify and implement workflow improvements to accelerate timelines, increase throughput, and enhance data quality
* Manage multiple programs in parallel, aligning priorities, timelines, and deliverables in a dynamic, matrixed environment
** Qualifications
* ** Ph.D. with 2+ years, or M.S. with 10+ years of industry experience in molecular biology, pharmacology, or a related field
* Experience in high-throughput screening and assay development in a drug discovery setting
* Experience with RNAi, ASO, or other oligonucleotide-based therapeutics
* Design, optimize, and execute high-throughput in vitro assays (e.g., transfection, free uptake, qPCR/Taq Man, reporter assays) across diverse cell types
* Strong understanding of transfection and free-uptake systems across suspension and adherent cell models, including primary systems
* Hands-on experience with laboratory automation platforms and scaling high-throughput operations
* Familiarity with automated data capture and analysis platforms
* Proven track record of delivering high-quality, reproducible data under tight timelines to inform decisions
* Demonstrated experience mentoring scientists and leading complex workflows
* Strong communication skills; able to provide clear, timely updates on program progress and key lab activities
* Comfortable working at the bench alongside associates to execute and troubleshoot experiments

Demonstrated success leading cross-functional initiatives and driving operational improvements#LI-JR1
** U.S. Pay Range****$ - $
** The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).Alnylam’s

robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k) with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave.

Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.
* Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website:
*** About Alnylam
** We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the…