Sr. Technical Program Manager, Infrastructure Rationalization

Role Overview

Moderna is seeking a Senior Technical Program Manager (TPM) to drive project and program management of infrastructure (cloud and on‑prem) rationalization and AI‑readiness initiatives at Moderna globally. We’re looking for someone with a high level of integrity and personal accountability, strong interpersonal skills, and infrastructure technology domain expertise.

• Program Management – take a structured, data‑driven, and risk‑based approach to program scoping, execution, and reporting.
• Kick off and successfully manage multiple, simultaneous, complex, high‑visibility work streams with full ownership, effective collaboration, and good process.
• Build processes, templates, and structure, or leverage existing ones as appropriate.
• Manage vendors, schedule, scope, and cost.
• Measure program success (or lack thereof) and risks using data and facts.
• Provide balanced risk remediation strategies and recommendations and drive risk mitigation.
• Develop and maintain close stakeholder relationships and build influence to drive the appropriate outcomes across Moderna.
• Provide clear, accurate, consistent, and timely communications.
• Advance good infrastructure and security practices and culture.
• Partner collaboration – work with Cloud Engineering, Systems Engineering, AI Engineering, Network Engineering, Identity and Access Management, Builder Tools & Platforms, IT, Cybersecurity, software engineering, and business stakeholders to manage and drive improvement projects in a structured and predictable manner.
• Manage multiple initiatives: cloud modernization; rationalize infrastructure platforms, tooling, and service models that underpin AI workloads; identify and eliminate redundant, unsupported, or non‑scalable infrastructure patterns that impede AI adoption; enable standardized, secure, and supportable “AI‑ready” infrastructure foundations that accelerate time‑to‑value while managing cost and risk; ensure infrastructure rationalization aligns with AI governance, data protection, and compliance requirements; define and track KPIs related to platform consolidation, cost optimization, risk reduction, and AI enablement readiness.
• Lead and drive infrastructure service management improvements and process optimization initiatives, including infrastructure patch and vulnerability management.
• Actively contribute to creating a more inclusive culture and environment at Moderna; endorse, create, and maintain antiracist policies and processes.

• 8+ years of program management experience, preferably in infrastructure engineering.
• Demonstrated technical depth, problem‑solving capabilities, and stakeholder and vendor management skills.
• Technical background in infrastructure engineering, with a strong understanding of ITSM.
• Experience in running programs within a cross‑functional, global team of mixed engineering, architecture, and operations.
• Ability to successfully scope and drive complex and multi‑workstream programs in a structured, risk‑considerate, data‑driven fashion.
• Strong listener with the ability to deeply understand, ask the right questions, and proactively pursue constructive feedback.
• Proven ability to operate in highly matrixed environments and influence without direct authority.

• Strong understanding of cloud platforms (AWS, Azure).
• Familiarity with infrastructure concepts: compute, storage, networking, containers, Kubernetes.
• Working knowledge of AI/ML infrastructure needs (GPUs, distributed training, data pipelines, MLOps).
• Influential, inclusive, and trusted partner compassionate to the needs and situations of all stakeholders.
• Deep familiarity with ITSM frameworks (e.g., ITIL).
• Experience driving structured, process‑driven infrastructure transformation initiatives.
• Knowledge of security and compliance standards relevant to infrastructure operations.
• Embrace a culture of continuous service improvement and service excellence.
• A desire to make an impact as part of a high‑growth, transformational company.
• Experience with GxP environments and regulatory requirements.

Best‑in‑class healthcare coverage, plus voluntary benefit programs to support your unique…