VP, Business Operations & Partnerships, Clinical Operations

Key Responsibilities

• Performance & Governance:
  Enable Pipeline Delivery to make informed, timely decisions through governance structures and performance frameworks.
  • Design and operationalize portfolio governance (e.g., cross-functional trial teams, Pipeline Delivery governance, escalation pathways).
  • Define roles, decision rights, and "decision-ready" materials to enable faster decision‑making.
  • Lead function performance tracking (milestones, risks, delivery confidence) and provide actionable insights to support prioritization and trade‑offs.
• Resource Planning & Management:
  • Develop and oversee capabilities to strategically plan and manage resources across Pipeline Delivery.
  • Design and implement resource planning frameworks for capacity, demand, and capability visibility.
  • Partner with Finance and functional leaders on portfolio strategy, budgets, and resource allocation.
  • Optimize internal staffing models and external partner utilization via vendor management tools/processes.
  • Ensure right capabilities/capacity for the evolving pipeline; provide scenario planning and forecasting insights.
• Vendor & Alliance Management:
  • Define and execute a centralized, forward-looking vendor strategy.
  • Provide oversight and performance management of external partners (e.g., CROs) across the clinical development portfolio.
  • Drive vendor governance/accountability for high-quality, cost-effective delivery; ensure alignment to timelines/priorities.
  • Lead partner relationship governance focused on value realization and risk mitigation.
• Leadership Responsibilities:
  • Build and lead a high-performing Portfolio Management organization.
  • Partner across Clinical Research, Program Management, Clinical Operations, Data Management, IT, Finance, and external partners.
  • Advise senior leaders on operating model design and execution effectiveness.
  • Champion collaboration, transparency, accountability, and innovation; build scalable capabilities.

• Bachelor’s degree + 20+ years biotech/pharma experience; expertise in Clinical Development Operations.
• Proven ability to design and operationalize governance/decision frameworks, escalation pathways, and portfolio performance management.
• Demonstrated success in operating model design/transformation.
• Ability to translate portfolio strategy into actionable operational plans (timelines, budgets, capabilities, priorities).
• Significant experience managing CROs/external service providers (vendor governance, performance management, contract oversight).
• Strong financial/business acumen (forecasting, budgeting, investment planning, scenario modeling).
• Experience creating executive insights/dashboards/metrics.
• Exceptional leadership and influencing in highly matrixed organizations.
• Strong strategic thinking/problem-solving; anticipate risks and evaluate trade-offs.
• Excellent communication and executive presence.
• Ability to lead change, build scalable operating models, and drive continuous improvement.
• Prior RNAi or complex multi-asset pipeline experience preferred.