Principal Scientist, Lab Head, Integrative Neuroscience

Job title
:
Principal Scientist, Lab Head, Integrative Neuroscience

• Location:
  
  Cambridge, MA

About the Job

We are seeking a highly skilled and motivated scientist to lead a team focused on developing novel therapeutics, with a preference for RNA-based approaches for neurological disorders. In this role, you will drive biology to identify therapeutic targets and advance these targets through the discovery pipeline by leading multidisciplinary project teams. The ideal candidate will bring deep expertise in neurological disorders with a particular emphasis on neuropsychiatric, neurodevelopmental, and/or seizure-related disorders.

Experience in RNA-based therapeutic modalities (siRNA and antisense oligonucleotides) is highly desirable.

Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

• Lead drug development programs by managing timelines, defining key scientific questions, and ensuring team focus.
• Establish in vitro and in vivo models for molecule testing, biomarker discovery, and exploratory biology.
• Interrogate human datasets to identify novel pathways and targets, and collaborate with platform teams to apply cutting‑edge genetic and genomic approaches for target credentialing.
• Contribute to programs using diverse therapeutic modalities, with an emphasis on gene knockdown/splicing technologies (e.g., siRNA and ASOs).
• Mentor team members, provide strategic and day‑to‑day guidance, and support laboratory execution.
• Perform laboratory experiments in partnership with team members.
• Implement AI into screening, experimental, and analysis workflows to accelerate discovery work.
• Collaborate effectively within matrixed, dynamic, and cross‑functional teams across the Neurology therapeutic area, platform groups, and external partners.
• Build and maintain a robust external scientific network to support portfolio advancement, collaborations, licensing opportunities, and business development activities.
• Compile, present, and clearly communicate scientific Progress to internal stakeholders, leadership, and external audiences.
• Publish scientific findings in peer‑reviewed journals and present results at scientific conferences.

Education:

• Ph.D. in neuroscience, neuropsychiatry, neurodevelopmental disorders, or a related field.
• A minimum of 3 years' experience in a drug development setting.

Experience & Technical

Skills:

• Prior drug development experience with RNA-based therapeutics. Knowledge of RNA conjugation, design, and delivery technologies.

Preferred Qualifications:

• Experience in neuropsychiatry and/or developmental disorders, including epilepsy.
• Understanding of ion channel biology and technical experience evaluating ion channel function.
• Ability to apply AI-based approaches to drug discovery.
• Demonstrated scientific creativity and productivity, evidenced by impactful publications in neurodevelopmental, neuropsychiatric, or epilepsy-related disorders.
• Deep expertise in cell-based disease models, including iPSC‑derived, primary neuronal systems, and complex co‑culture models.
• Strong understanding of in vivo pharmacology in rodents and/or non‑human primates. Direct hands‑on experience preferred.
• Ability to effectively define experimental goals and communicate scientific progress with colleagues and stakeholders from diverse backgrounds.
• Excellent analytical, presentation, and scientific writing skills.

• Bring the miracles of science to life alongside a supportive, future‑focused team.
• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
• Enjoy a thoughtful, well‑crafted rewards package that…