Manager, Commercial Supply Chain

At Agios, we are fueled by connections to transform rare diseases. We foster an inclusive, collaborative culture – one that sparks bold thinking and strengthens our connections with each other and with the rare disease communities we serve. We embrace diverse backgrounds with respect, active listening, and a commitment to inclusion – because our differences shape how we hire, collaborate, and innovate.

Our team s proven track record of executional excellence, combined with our depth of expertise and dedication, enables us to develop innovative medicines that reflect the priorities of rare disease communities. Our commitment is more than scientific – it’s deeply personal, grounded in the meaningful connections we have built.

Agios Pharmaceuticals is searching for a dynamic Manager, Commercial Supply Chain to join our growing team. Agios outsources all cGMP manufacturing operations to third‑party CMOs across API, bulk drug product, and final packaged goods. The selected individual will have full exposure across the different areas of the commercial supply chain and across early clinical to new commercial product launches. The individual will also support our growing global footprint as our distribution expands to other markets outside of the US, which will include responsibilities for life‑cycle management.

Additionally, this role will support the commercial supply chain department across systems, planning and operations.

• Work as a member of cross‑functional teams that include CMC, QA, and Regulatory; execute activities for Commercial Supply Chain Operations team on assigned projects.
• Oversee timelines for internal activities and external production activities at Contract Manufacturing Organizations (CMOs) to ensure continuous supply of commercial and clinical materials through the supply chain.
• Ensure accurate inventory in Agios’ inventory management system, including production data entry and reporting.
• Support commercial artwork changes for existing products and collaborate with the artwork team to develop new artwork for new product or market launches.
• Own change controls and support deviation investigations and other quality events.
• Collaborate with Finance and Cost Accounting teams to ensure proper inventory accounting and financial reporting.
• Issue purchase orders and track invoices to keep the project budget maintained.
• Maintain and communicate production schedules at all inventory levels.
• Oversee and maintain production KPIs for each supplier.
• Manage project‑department initiatives, including product launch activities, to ensure action items are tracked against a project plan.
• Support supply planning for both clinical and commercial supply chains as needed.

• BS degree in Engineering, Business, Supply Chain/Material Management, or a life‑science field.
• 5+ years of experience in supply chain or GMP manufacturing environment.
• Experience using ERP/SAP.
• Ability to travel up to 25% for production or supplier oversight.
• Detail‑focused, able to influence suppliers and projects with minimal oversight, while working collaboratively in a team environment.

• Experience working with CMO partners.
• Experience with new product launches.
• Experience with continuous manufacturing.
• Experience with EU/GCC regional requirements.

Location agnostic. The role can be remote in the US or hybrid at our Cambridge Headquarters. Hybrid schedules vary but generally involve less than 3 days per week onsite; hybrid employees are expected to live within commutable distance to the Cambridge Headquarters. Remote employees work entirely from home, except for attending company‑sponsored events and meetings. For employees who choose to work remotely, travel may be required for certain company events commensurate with the job description.

• Deliberate Development – your professional growth is a top priority.
• Flexibility – we embrace different perspectives and work styles to support each employee’s needs.
• Premium benefits package – a well‑rounded and flexible program to meet the varying personal and…