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Operating Principal, Summit PBU

Job in Cambridge, Middlesex County, Massachusetts, 02140, USA
Listing for: InforCapital, partnership
Full Time position
Listed on 2026-06-23
Job specializations:
  • Management
    Business Management & Consulting, Business Analyst, Corporate Strategy
  • Business
    Business Management & Consulting, Business Analyst, Corporate Strategy
Salary/Wage Range or Industry Benchmark: 150000 - 250000 USD Yearly USD 150000.00 250000.00 YEAR
Job Description & How to Apply Below
# Operating Principal, Summit PBUFlagship Pioneering Principal Venture  Capital Date Posted June 14, 2026

Stay ahead of the market

Get instant notifications when new job openings matching "Venture Capital / Principal jobs" are published.## About This Role Flagship Pioneering, the venture creation firm behind Moderna and other breakthrough life sciences companies, is seeking an Operating Principal to join its Summit Pioneering Business Unit (PBU) in Cambridge, MA.About Flagship Pioneering:

Flagship is a unique biotech innovation company that invents and builds platform companies that originate, discover, and develop life sciences products. The firm has generated over $90 billion in aggregate value and has been involved in the creation of more than 100 scientific ventures. Summit PBU is a business unit within Flagship focused on launching and scaling new portfolio companies (New Cos) at the intersection of science and business.

Role Overview :

This role is ideal for an entrepreneurial leader who thrives in ambiguity, moves seamlessly between science and business, and is energized by building organizations from inception to growth. The Operating Principal will work across one or more New Cos, leading operations and strategy, driving corporate development, and partnering closely with scientific leadership to translate breakthrough ideas into impact.

Key Responsibilities:

- Lead strategy and operational planning across one or more early-stage New Cos
- Drive corporate development initiatives including partnerships, financings, and strategic alliances
- Engage with Boards of Directors and key external stakeholders
- Collaborate directly with scientists and company leaders to align technical progress with operational goals
- Recruit, develop, and manage high-performing teams across functions
- Partner with Flagship central teams (Finance, Talent, Legal/IP, HR) to build best-in-class infrastructure at each New Co
- Execute operating and long-range plans ensuring milestones are achieved on time and on budget
- Build and maintain relationships with investors, partners, and key opinion leaders in the life sciences ecosystem

Qualifications:

- 10+ years of experience in biotech, pharma, or life sciences strategy and operations
- Prior management consulting experience a plus
- Proven success in strategic, operational, or corporate development leadership in early-stage biotech
- Strong scientific acumen with the ability to translate novel science into operational plans
- Track record of building and motivating high-performing teams

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