Senior Director, Program Leader, Corporate Strategy

Senior Director, Program Leader, Corporate Strategy

At Agios, we are fueled by connections to transform rare diseases. We foster an inclusive, collaborative culture that sparks bold thinking and strengthens our connections with the rare disease communities we serve. Our team’s proven track record of executional excellence, depth of expertise and dedication enables us to develop innovative medicines that reflect the priorities of rare disease communities. Learn more at  or follow Agios on Linked In and X.

Agios Pharmaceuticals seeks a visionary Program Leader to serve as single point of accountability for a critical clinical stage program. You will own the vision and drive execution from clinical development through regulatory approval, launch, and lifecycle management, aligning a high‑performing cross‑functional organization around a unified strategy.

• Own fully integrated global asset strategy across the entire product lifecycle, ensuring alignment with Agios’ portfolio.
• Define and continuously evolve the Target Product Profile, Clinical Development Plan, regulatory pathway, market access strategy, and commercial positioning.
• Identify, assess, and proactively communicate program risks and opportunities to senior leadership, developing mitigation strategies.
• Lead asset presentations at governance meetings to secure endorsement, budget, and resources.
• Drive competitive intelligence and external landscape assessment.
• Champion a patient‑first mindset in all strategic decisions.

• Lead the Program Team, building a cohesive, high‑performing cross‑functional team.
• Partner with the Program Manager to develop integrated execution plans, timelines, and resource requirements.
• Drive timely, well‑reasoned decision‑making across the organization.
• Ensure key program documents reflect full cross‑functional input and are kept current.
• Lead and mentor sub‑team leaders, fostering a culture of accountability and continuous improvement.

• Partner with Regulatory Affairs to guide global regulatory strategy and plan interactions with FDA, EMA, and other authorities.
• Ensure alignment of the development plan with commercial objectives, anticipating market access challenges.
• Collaborate with Medical Affairs and Clinical Development to define and execute publication strategy.
• Anticipate and navigate evolving regulatory and reimbursement landscapes globally.

• Serve as a key internal champion and external representative, engaging opinion leaders, patient advocacy organizations, and the scientific community.
• Partner with Investor Relations and Corporate Communications to develop external messaging.
• Collaborate with Business Development to evaluate and pursue lifecycle opportunities.
• Identify synergies and cross‑asset learnings across Program Teams.

• Model Agios’ values and culture, cultivating collaboration, intellectual courage, and patient focus.
• Communicate with clarity, candor, and executive presence.
• Recruit, coach, and develop team members across the program.
• Promote a culture of bold yet disciplined risk‑taking and innovation.

• Advanced degree (MD, PhD, PharmD, MBA, or equivalent); graduate‑level scientific or clinical training strongly preferred.
• 10+ years (Sr. Director) or 12+ years (VP) of progressive experience within pharma, biotech, or biopharma, including leadership of late‑stage or registration‑enabling programs.
• Demonstrated ability to drive successful product launch and commercialization, including lifecycle management.
• Deep expertise across clinical development, regulatory strategy, CMC, medical affairs, and commercial readiness, with rare disease experience desired.
• Proven track record as a decisive strategic leader in a global matrix organization.
• Experience leading cross‑functional global program teams through major regulatory milestones.
• Strong business acumen with experience integrating program plans into long‑range corporate strategy.
• Exceptional communication skills, both written and verbal, to diverse…