Clinical Program Manager, Cambridge, MA

Clinical Program Manager – Cambridge, MA

Isomorphic Labs (Iso Labs) is developing and applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life‑changing medicines. The company’s ambitious mission is to one day solve all disease.

The experienced Clinical Program Manager will help to lead the transition of our internal programs from pre‑IND to clinical trial execution. Reporting to the Program Lead, this critical role will work with the cross‑functional global team to drive clinical trial execution, managing timelines, risks, budgets and vendor partnerships. The role leverages AI and emerging technologies to ensure efficient outcomes with a high probability of success.

• Project planning and execution:
  Develop and own integrated project plans that track operational strategy, timelines, risks and dependencies across work streams to ensure alignment between clinical objectives and company goals.
• Cross‑functional leadership and communication:
  Act as the central point of contact ensuring high performance and alignment among the cross‑functional clinical trial team.
• Lead project team meetings ensuring effective information sharing, decision making and documentation.
• Collaborate with preclinical program managers as well as AI/ML and data science teams to identify and implement new solutions to increase speed, scale and probability of success.
• External partnerships:
  Oversee and manage a network of external vendors, CROs, partners and collaborators, including budgets, timelines and key deliverables.
• Stakeholder management:
  Provide regular updates to leadership and key stakeholders on clinical study execution and portfolio management.
• Proactively and in real‑time help teams to problem‑solve and identify issues that impact key deliverables, timelines and budgets.

• Proven track record of managing a clinical program from IND through late‑stage clinical development, within expected timelines and budgets.
• Experience working cross‑functionally with key stakeholders internally as well as external vendors and collaborators. Excellence in building relationships in both settings.
• Highly organized, with experience managing large budgets and complex interdependent timelines using project management tools.
• Strong sense of urgency and accountability in a fast‑paced environment.
• Flexibility to adapt to changing timelines and priorities.
• Strong leadership and excellent communication skills.
• Willingness and ability to motivate and hold interdisciplinary teams and vendors accountable to ensure on‑time and within‑budget execution.

• Formal program management qualification (e.g., PMP).
• Experience working as part of a global team across countries.

• Thoughtful: Curiosity, creativity and care; rigorous and future‑making science every day.
• Brave: Fearlessness with initiative and integrity.
• Determined: Confidence in our hypothesis, urgency and agility to deliver.
• Together: Connection, collaboration across fields and catalytic relationships that impact people worldwide.

We follow a hybrid model and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on your team). If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to discuss accommodations if you’re selected for an initial screening call.

We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know.