Sr Director, Clinical Excellence Group Lead (I&I

The Inflammation & Immunology Clinical Excellence & Innovation organization is seeking an experienced and enterprise-minded clinical development leader to serve as Senior Director, Clinical Excellence Group Lead. This highly visible role provides strategic clinical, scientific, operational, and people leadership across a portfolio of complex clinical development programs.

The successful candidate will lead and develop a team of clinical scientists while ensuring clinical integrity, scientific quality, patient safety, and disciplined execution across studies. This leader will also help advance new ways of working, including the responsible integration of AI-enabled, digital, data, and advanced analytics capabilities to improve clinical development quality, speed, and decision-making.

• Lead, mentor, and develop a team of high-performing clinical scientists, fostering a culture of collaboration, accountability, continuous learning, intellectual curiosity, and agility.

• Act as a change champion, guiding a highly tenured organization through digital transformation and new ways of working.

• Drive change management initiatives that encourage the adoption of innovative tools and process optimizations without compromising scientific rigor.

• Build strong, collaborative partnerships with Clinical Operations, Data Science, Biostatistics, Digital/Technology, Regulatory, Medical Affairs, Portfolio Strategy, and Business Operations to align clinical science objectives with broader enterprise goals.

• Apply strong business acumen to identify operational bottlenecks within clinical development and lead cross-functional work streams to design and implement scalable solutions.

• Develop and implement fit-for-purpose operating practices, tools, and governance approaches that enable a well-controlled, flexible organization with strong fiscal management, cross-team communication, and efficient workflows.

• Establish and leverage standardized frameworks to evaluate clinical program designs, resource needs, and workflows through an operational efficiency lens, ensuring resources are optimized and key milestones are supported.

• Partner with Finance and Corporate/Portfolio Strategy functions to build financial models and scenario analyses that inform program- and portfolio-level decision-making.

• Develop business insights, metrics, and dashboards to inform decision-making, monitor therapeutic area performance, and identify opportunities to improve quality, speed, productivity, and portfolio impact.

• Navigate a complex matrix environment with an enterprise mindset, ensuring that innovation strategies in I&I can scale and align with broader Pfizer corporate objectives.

• Lead the identification, strategic development, and implementation of AI/ML and advanced analytics tools to optimize clinical trial design and execution.

• Direct applied AI/ML approaches across the continuum, including:

• Protocol design and optimization

• Site selection and feasibility assessment

• Patient recruitment and enrollment strategies

• Query management and workflow automation

• Data cleaning, anomaly detection, and signal identification

• Safety risk prediction and proactive mitigation

• Partner closely with data science, digital, and technology teams to translate complex AI use cases into practical, scalable, compliant workflows for study teams.

• Incorporate AI-derived insights and data-driven approaches into overarching clinical strategy and regulatory deliverables.

• Oversee the clinical execution and integrity of a portfolio of medium- to high-complexity clinical studies within the I&I pipeline.

• Provide senior-level clinical oversight in protocol design, development, and strategic clinical documentation (protocols, CSRs, regulatory submissions).

• Oversee clinical data review, safety surveillance, and risk management at the program level.

• Serve as a senior clinical escalation point and strategic partner for Product Team Leads, Global Development Leads, investigators, and internal study teams.

• Contribute to evaluation of external…