Sr. Director, Alliance and Program Management

Sr. Director, Alliance and Program Management

Cambridge, MA USA

Pro Found™ Therapeutics is a biotechnology company discovering novel proteins across the expanded human proteome to unlock transformative drug targets and first-in-class medicines. The company’s proprietary Pro Foundry™ Platform integrates state-of-the-art protein detection, validation, and computational technologies to systematically identify and characterize previously unknown proteins and validate their therapeutic potential. This approach has generated a rapidly expanding portfolio of novel targets and programs advancing toward the clinic, along with strategic collaborations with leading pharmaceutical partners.

Together, these efforts support the development of breakthrough treatments across a broad range of disease areas. For more information, please visit  .

Pro Found Therapeutics is seeking a Senior Director, Alliance & Program Management to serve as an operational and strategic partner to the Chief Operating Officer, leadership team, and program teams.

This role has two primary responsibilities: (1) serving as the day-to-day operational leader for Pro Found's strategic pharmaceutical collaborations and (2) building the company's portfolio and program management capabilities. The role ensures successful alliance and program execution while developing the governance, planning processes, and operating systems that enable disciplined execution across the company's growing portfolio. This is a highly visible role requiring exceptional judgment, operational rigor, and the ability to influence without authority.

The successful candidate will lead day-to-day alliance execution, enable governance, implement practical program management systems, and partner with scientific leadership to translate decisions into disciplined execution and ensure that programs remain aligned on objectives, timelines, budget, risks, and resource needs.

The ideal candidate is an experienced biotechnology operator who combines strategic thinking with hands‑on execution. They thrive in a lean, entrepreneurial environment where priorities evolve rapidly and success depends on bringing structure to complexity, building practical solutions, fostering collaboration, and driving accountability across highly matrixed teams.

• Serve as the primary Alliance Manager and operational leader for Pro Found's strategic pharmaceutical collaborations, ensuring successful execution of scientific objectives, governance activities, and contractual commitments.
• Build trusted relationships across partner organizations while coordinating cross-functional scientific, legal, finance, IP, and operational teams to drive alliance execution.
• Lead Joint Steering Committees (JSCs) and other governance forums, ensuring meetings are well prepared, decisions documented, and actions successfully executed.
• Partner with Business Development to help structure new alliances for successful execution.
• Translate collaboration agreements into executable operating plans, proactively managing milestones, deliverables, risks, issues, and partner expectations.
• Monitor alliance health and performance, resolving conflicts constructively and providing executive leadership with clear visibility into key risks and opportunities.
• Build credibility through exceptional execution, proactive communication, sound judgment, and effective stakeholder management.

• Build and continuously improve Pro Found's portfolio and program management capabilities, including governance, tools, and operating processes.
• Lead integrated program management across discovery and early development programs, ensuring visibility into progress, risks, and resource needs.
• Train and support scientific teams in adopting practical project management tools and consistent execution practices.
• Partner with scientific leadership to implement stage-gate processes, governance frameworks, and portfolio reporting that support timely, high-quality decisions.
• Partner with Finance to integrate program plans, budgets, and decision points, framing up options for timely investment,…