Senior Director, Program Leader

At Agios, we are fueled by connections to transform rare diseases. We foster an inclusive, collaborative culture – one that sparks bold thinking and strengthens our connections with each other and with the rare disease communities we serve. We embrace diverse backgrounds with respect, active listening, and a commitment to inclusion – because our differences shape how we hire, collaborate, and innovate.

Our team’s proven track record of executional excellence, combined with our depth of expertise and dedication, enables us to develop innovative medicines that reflect the priorities of rare disease communities. Our commitment is more than scientific – it’s deeply personal, grounded in the meaningful connections we have built. To learn more, visit  and follow Agios on Linked In and X.

Agios Pharmaceuticals is searching for a visionary and strategic Program Leader to serve as the single point of accountability for one of our critical clinical stage programs. This is a rare opportunity to function as the strategic and operational architect of a clinical stage asset, owning its vision and driving its execution from clinical development through regulatory approval, global launch, and lifecycle management.

As the Program Leader, you will lead the Program Team, aligning a high-performing cross-functional organization around a unified strategy designed to deliver transformative therapies to patients with rare diseases. You will be a decisive, globally-minded leader who thrives at the intersection of science, strategy, and execution — equally comfortable engaging with Senior Leadership and rolling up your sleeves to resolve complex challenges.

• Own the fully integrated global asset strategy across the entire product lifecycle — from development candidate through clinical proof of concept, regulatory approval, commercial launch, and lifecycle management — ensuring alignment with Agios’ portfolio and corporate objectives.
• Define and continuously evolve the Target Product Profile, Clinical Development Plan, regulatory pathway, market access strategy, and commercial positioning in close partnership with cross-functional leaders and aligned with patient needs.
• Identify, assess, and proactively communicate program risks and opportunities to senior leadership and governance bodies, developing clear mitigation strategies and scenario-based contingency plans.
• Lead asset presentations at governance meetings to senior leadership, securing endorsement, budget, and resource allocation through rigorous analysis of strategic options, return on investment, and risk.

• Lead the Program Team, building a cohesive, high-performing cross-functional team that includes, but is not limited to, Clinical Development, Regulatory Affairs, Commercial, Medical Affairs, Manufacturing/CMC, Market Access, Finance, Legal, and Program Management.
• Partner closely with the Program Manager to develop integrated execution plans, timelines, and resource requirements; maintain accountability for delivering against program goals, milestones, and budgets.
• Drive timely, well-reasoned decision-making across the organization, using governance structures effectively to resolve complex tradeoffs and keep programs on track.
• Ensure that all key program documents reflect full cross-functional input and are kept current.

• Partner with Regulatory Affairs to guide the global regulatory strategy, including planning and preparation for interactions with the FDA, EMA, and other major health authorities; experience with and understanding of NDA/BLA or equivalent submissions is central to this role.
• Ensure alignment of the development plan with commercial objectives, partnering with the Commercial team to anticipate market access challenges and build a globally competitive value proposition.
• Collaborate with Medical Affairs and Clinical Development to define and execute the asset’s publication and data dissemination strategy across major scientific congresses and peer-reviewed journals.
• Anticipate and navigate evolving regulatory and reimbursement…