Head of Global Investigative Toxicology

Job Title: Head of Global Investigative Toxicology

Location: Cambridge, MA

Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

In the pharmaceutical industry, one of the major challenges in the discovery of innovative medicines is to ensure they are safe enough to serve patients – that is our mission. Drug safety is assessed throughout the R&D value chain, but it is during early drug discovery when we can actively design safety attributes into future candidate drug. We are supporting Drug Hunting partners in identification and optimization of new biological and synthetic molecule series applying cutting edge technologies pushing to the boundaries of predictive safety science with our mission in mind.

We are also committed to the application of the 3

Rs principles and to the implementation of New Alternative Methodologies (NAMs) in preclinical safety assessment.

We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

For our global investigative toxicology efforts we are looking for a strong Leader with focus on Investigative Toxicology. Activities include, but are not limited to:

• Leading our global investigative toxicology efforts with operations in Boston, Paris and Montpellier and with Senior Scientific Advisors serving as global safety experts in various toxicology disciplines based in multiple countries (France, US and Germany); develop/evolve strategy, ensure alignment and rationalization of activities across sites; ensure reaching out to internal and external ecosystem to develop/maintain networks and ensure access to appropriate methodologies/vendors;
  
  reach to other functions in R&D (Translational Medicine Unit, Research and Development) to share technologies / use synergies as applicable. Advice Preclinical Safety Project teams reps on building investigative toxicology strategy / review given strategies to progress projects successful overcoming challenges or rationale termination.
• Reporting to global Head PCS and Member of the global Leadership Team.
• Manage Senior Scientific Advisors globally.
• Strongly interact with Heads of Research Projects and Development projects.
• Develop together innovative solutions and research proposals to pursue cutting edge science and technologies in order to optimize and influence translational safety assessment of novel drug targets.
• Facilitate and promote the use of new alternative methods (NAMs) in preclinical safety regulatory and non-regulatory testing.
• Serve globally as internal expert for discovery and development projects and design project-specific strategies to predict, assess and mitigate target- and modality-related safety risks and execute through internal and external experimental capabilities.
• Engage with experts across the organization to ensure that teams are able to make the right decisions regarding the translational safety risks associated with the project.
• Continuously interact with multiple R&D functions (TMU departments, Research and Development TAs, Research Platforms, etc ..) to identify opportunities to collaborate and utilize technologies across R&D more efficiently.
• Participate in special projects or inter-industry working groups, as needed. Provide scientific input on design and analysis of research activities and contribute to Sanofi Outreach activities.
• Ensure high scientific standards / adhering to requested timelines in all aspects of the position.
• Supervision / Development of laboratory staff and global experts.

• PhD or DVM and post-doctoral experience in toxicology, biochemistry, pharmacology, cell biology or systems biology. In addition, the candidate should have knowledge in biochemistry, toxicology, pharmacology,…