Senior Associate Scientist- In Vivo Pharmacologist

Overview

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Job Title: Senior Associate Scientist - In Vivo Pharmacologist

Posted Date: Feb 4, 2026

Duration: 0 Month, Direct Hire (Full Time)

Shift(s): 09:00 - 17:00

Salary: $68,600.00 - $ per year (compensation based on experience and qualifications)

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Employer: Rangam is seeking candidates for a Direct Hire role as a Senior Associate Scientist - In Vivo Pharmacologist with Pfizer, one of the world’s largest pharmaceutical companies. Candidates in Cambridge, MA or willing to relocate are encouraged to apply.

Location: Cambridge, MA (or relocation)

At Pfizer, our mission is to deliver breakthroughs that transform patients’ lives. In the Inflammation and Immunology Therapeutic Area, we translate cutting-edge science and technology into impactful therapies for autoimmune and inflammatory diseases.

The Preclinical In Vivo Pharmacology group seeks a highly motivated Senior Associate Scientist to support the expansion, optimization, and application of in vivo platforms, with a focus on humanized systems, including human stem cell engrafted mouse models.

You will design and execute studies to characterize emerging in vivo models and evaluate the efficacy and mechanisms of novel small- and large-molecule therapeutics. Responsibilities include aseptic handling of immunocompromised animals, dosing, tissue collection, and ex vivo analyses such as flow cytometry and MSD immunoassays. You will analyze, interpret, and communicate high-quality data to advance program decision-making and contribute to our therapeutic portfolio.

Join our collaborative team and help drive impactful science that improves patient outcomes.

In this role, you will:

• Expand critical capabilities by designing and executing comprehensive in vivo model-development studies
• Support the portfolio by planning and conducting pharmacology studies to evaluate mechanisms of action and therapeutic efficacy for pipeline molecules
• Perform specialized research using human cell-engrafted immunocompromised mice, including aseptic execution of cell preparation and in vivo techniques
• Profile models and drug performance through tissue collection and ex vivo assays, including flow cytometry and multiplex immunoassays
• Generate high-quality data packages with well-documented methods, analyses, and interpretations for project team presentations
• Enhance operational efficiency and scientific impact by collaborating with partner line colleagues, including modelers and statisticians, and across in vivo teams, including neuro- and lung-inflammation-focused groups

• Bachelor’s Degree with 3 years of relevant experience or Master’s Degree with 1 year of relevant experience
• Foundational knowledge of immunology, autoimmunity, and pharmacology
• Experience in in vivo preclinical research, ideally in a biotech or pharmaceutical environment
• Proficiency with in vivo techniques, including intraperitoneal, oral, and intravenous dosing; submandibular bleeds; aseptic handling of immunocompromised mice; and tissue collection
• Hands-on experience with tissue processing and execution of molecular biology techniques, including flow cytometry, multiplex immunoassays, and RT-PCR
• Proficiency with data analysis and documentation tools like Excel, Graph Pad Prism, Flow Jo, PowerPoint, and Signals Electronic Lab Notebook
• Strong time-management skills with the ability to follow established protocols, develop new methods, and troubleshoot independently
• Excellent written and verbal communication skills; strong organizational skills; and attention to detail
• Ability to work independently as well as collaboratively within multidisciplinary teams

• Experience with cell culture and human primary cell handling
• Familiarity with animal models of neuroinflammation and/or lung inflammation, including techniques such as intracerebroventricular…