Senior Scientist - Quantitative Systems Pharmacology; QSP Modeling

Role Summary

The Senior Scientist, QSP Modeling will develop and apply mechanistic quantitative systems pharmacology models to support drug discovery and development. This role focuses on hands-on model development, integration of biological and clinical data, and generation of insights to guide dose selection, target validation, and clinical strategy.

• Develop, calibrate, and validate mechanistic QSP models to describe disease biology, drug mechanism of action, and PK/PD relationships.
• Integrate diverse data sources (in vitro, in vivo, clinical, omics, literature) into QSP modeling frameworks.
• Perform model-based simulations to support:
  • Target and pathway evaluation
  • Dose and regimen selection
  • Biomarker strategy
  • Translational predictions from preclinical to clinical stages
• Collaborate closely with cross-functional teams including Biology, Pharmacology, Clinical Pharmacology, Biomarkers, and Translational Medicine.
• Document model assumptions, structure, qualification, and limitations according to internal and regulatory standards.
• Prepare technical reports, presentations, and visualizations to communicate model insights to project teams.
• Contribute to publications, posters, and internal scientific forums.
• Maintain awareness of emerging QSP methodologies, tools, and best practices.

• PhD (or equivalent) in Pharmacology, Systems Biology, Bioengineering, Applied Mathematics, Chemical Engineering, or a related quantitative discipline.
• 2–5 years of experience applying QSP or mechanistic modeling in pharmaceutical or biotech settings (or equivalent postdoctoral + industry experience).