Spatial Biology Platform Scientist

Cambridge, MA (In-person)

GT Biosciences is building Deliveromics, the world’s first AI-powered, high-throughput, and multiplexed in vivo data engine for decoding the design rules of drug delivery. Founded by MIT scientists and backed by top-tier investors, we are creating next-generation non-viral, cell-type-specific delivery vehicles, including early success in crossing the blood–brain barrier and transfecting specific brain cell types. We are a tightly-knit, fast-moving, and science-driven team dedicated to making routine in vivo cell reprogramming a reality.

We’re a small, fast-moving, science-obsessed team on a mission to make routine in vivo cell reprogramming possible. We value transparency and collaboration, and seek teammates who thrive in an open, cooperative environment and want to grow together with the team and the company.

GT Biosciences is seeking a highly mission-driven, multidisciplinary Spatial Biology Scientist to join our Platform Development Team and help advance our Deliveromics platform. The ideal candidate brings deep expertise in spatial biology, nucleic acid sequencing, and assay development, with a passion for transforming complex experimental workflows into robust, automated, and scalable processes. As one of the earliest scientific hires, you will collaborate closely across biology, chemistry, and engineering to generate high-quality data and insights that propel and shape the Deliveromics platform innovations.

You will contribute directly to a transformative technology that provides systematic solutions to cell-specific drug delivery in vivo. This is a full-time, in-person position based in Cambridge, MA.

• Optimize and refine assay workflows for in situ barcode sequencing, ensuring high robustness, reproducibility, and sensitivity.
• Design and execute experiments at the interface of chemistry and molecular biology to advance spatial readout performance.
• Direct contributions to assay chemistry: probe design, hybridization kinetics, signal generation and amplification, or multiplexing strategies.
• Work collaboratively across teams to troubleshoot issues, solve technical challenges, and integrate new methods into the Deliveromics platform.
• Analyze experimental results using rigorous quantitative approaches, generate clear technical reports, and provide actionable recommendations that guide platform development.
• Apply statistical and process-evaluation tools to assess workflow quality, identify variability, and support data-driven optimization.
• Maintain thorough documentation, including protocols, SOPs, experimental records, and analysis reports, to ensure full reproducibility.
• Drive process innovation and contribute to technology transfer as workflows become more automated, scalable, and production-ready.

Required:

• PhD in Bioengineering, Biomedical Engineering, Biochemistry, Biophysics, or a related discipline. Strong candidates demonstrating significant experience without doctoral degrees will be considered.
• Hands‑on experience developing, engineering, or building probe/chemistry development, image acquisition pipelines for spatial biology technologies, such as novel FISH‑based assays, in situ sequencing chemistries, spatial transcriptomics or proteomics platforms.
• Experience rooted in building and understanding novel technologies, not simply the end‑use of commercial platforms.
• Strong understanding of relevant computational workflows.
• Practical experience with tissue processing workflows, such as fresh‑frozen and FFPE preparation, cryosectioning, and antigen retrieval.
• Experience operating, optimizing, and troubleshooting optical imaging systems, including confocal or fluorescence microscopy.
• Exceptional problem‑solving skills, attention to detail, and experimental rigor.
• Excellent written and verbal communication skills, with the ability to collaborate effectively across diverse scientific and technical teams.
• A resourceful, adaptable, and emotionally intelligent team player who thrives in fast‑paced, cross‑functional environments.
• Ability to work onsite five days per week at our Cambridge, MA location.

• Deep…