Scientist, Retinal Degeneration

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* Job Title:

** Scientist, Retinal Degeneration
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* Location:

** Cambridge, MA
** About the Job
** Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

Sanofi is seeking a highly motivated Scientist to conduct preclinical drug discovery research for retinal diseases, including age-related macular degeneration and glaucoma. As a Scientist in the Retinal Degeneration group within Ophthalmology Research, you will design and execute studies to validate therapeutic strategies and discover promising drug candidates. The successful candidate will work collaboratively in matrixed, cross-functional teams to generate high-quality and comprehensive data packages to nominate and advance therapeutic candidates toward clinical development.

This position offers the exciting opportunity to make significant contributions to the future of ophthalmology therapeutics and bring transformative vision-preserving treatments to patients around the world.

We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.
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* Main Responsibilities:

*** Design, execute, and document research studies to validate therapeutic targets and discover preclinical drug candidates
* Develop and optimize molecular, biochemical, and cellular assays to assess disease processes, target activity, and biomarkers in models of retinal disease and degeneration
* Perform experiments using genetic, biologic, and small molecule perturbations to validate targets, evaluate therapeutic strategies, and assess the pharmacology and efficacy preclinical candidates
* Analyze and interpret experimental data to support target prioritization, preclinical candidate selection, and go/no-go decisions
* Actively contribute to interdisciplinary research projects in a highly collaborative and matrixed manner
* Prepare high-quality presentations and documentation to support project deliverables, publications, patent filings, and regulatory filings
* Effectively communicate findings internally and externally through presentation and publication
** About You
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* Basic Qualifications:

*** Earned Bachelor’s degree in biological sciences, bioengineering or other relevant field and 6+ years of research experience in an academic or biopharmaceutical setting OR earned Master’s degree in biological sciences, bioengineering or other relevant field and 3+ years research experience in an academic or biopharmaceutical setting
* Solid understanding of degenerative disease mechanisms required, with experience in retinal disease and degeneration or neurodegeneration research strongly preferred
* Experience in drug development required, preferably within the biopharmaceutical industry
* Experience with a broad range of molecular, cellular, and biochemical methods and assay development
* Extensive cell culture experience, including work with primary cells, iPSC-derived cells, or 3D
* in vitro
* models* Experience designing, executing, and interpreting
* in vitro
* experiments using genetic or pharmacologic approaches to assess gene and protein function, signaling pathway activity, and/or cellular processes
* Demonstrated ability to prepare high-quality documents including experimental protocols, SOPs, technical reports, and presentations
* Track record of impactful contributions to research projects and scientific publications
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* Preferred Qualifications:

*** Experience using computational tools (e.g., R, Python) to analyze data strongly preferred
* Experience evaluating target engagement and efficacy of preclinical candidates
* Experience developing high-throughput assays and using automated screening platforms and robotics
* Experience with live-cell and high-content imaging and analyses
* Experience authoring regulatory documents to support IND or CTA submissions
** Skills…