Research Scientist – Discovery Biosciences, Oncology; Onsite – Cambridge, MA

Overview

Research Scientist – Discovery Biosciences, Oncology (Onsite – Cambridge, MA)

We are seeking a Research Scientist – Discovery Biosciences, Oncology for a global pharmaceutical client. This position is heavily focused on wet lab work, contributing to cutting-edge research projects aimed at understanding cancer biology, identifying novel drug targets, and developing new therapeutic approaches. The successful candidate will work in a collaborative and dynamic environment alongside leading scientists in the field of oncology.

This is a 40-hour per week, 7-month contract (extensions possible), 100% onsite role at the client’s office in Cambridge, MA. This is a W2 role as a Stage 4 Solutions employee. Health benefits and 401K are offered.

• Conduct full time laboratory-based research supporting target identification, oncology drug discovery and development.
• Execute a variety of molecular biology, cellular biology, and biochemical assays, including:
• Maintenance and manipulation of 2D and 3D cell cultures, including spheroids and organoids.
• Lentiviral and nucleofection based gene transfer and genome editing.
• Target gene perturbation using CRISPR/Cas9 and Cas
  12, shRNA and siRNA.
• Cell viability and cytotoxicity assays using Incu Cyte, Cell Titer-Glo, CyQUANT and clonogenic assays.
• Large scale functional genetic and phenotypic screens.
• RT-qPCR and western blot, sample prepping for RNA-seq.
• Co-immunoprecipitation (coIP), and other protein interaction studies.
• ELISA, Meso Scale Discovery (MSD), and other immunoassays.
• Design, optimize, and troubleshoot complex cell-based assays to evaluate therapeutic candidates and understand cancer signaling pathways.
• Collaborate with cross-functional teams, including medicinal chemistry, bioinformatics, and in vivo pharmacology, to advance project goals.
• Analyze and interpret experimental data, maintain accurate and detailed lab records, and present findings in team meetings.
• Contribute to the preparation of technical reports, publications, and presentations.

• 4+ years of experience in a variety of molecular biology, cellular biology, and biochemical assays, including:
• Maintenance and manipulation of 2D and 3D cell cultures, including spheroids and organoids.
• Lentiviral and nucleofection based gene transfer and genome editing.
• Target gene perturbation using CRISPR/Cas9 and Cas
  12, shRNA and siRNA.
• Cell viability and cytotoxicity assays using Incu Cyte, Cell Titer-Glo, CyQUANT and clonogenic assays.
• RT-QPCR and western blot, sample prepping for RNA-seq.
• Extensive experience with oncology research, cancer biology, and drug discovery processes is preferred
• Experience with advanced techniques such as high-content imaging and flow cytometry is preferred
• Proficiency in data analysis software (e.g., Graph Pad Prism, Flow Jo) and familiarity with bioinformatics tools is preferred
• Bachelor’s or Master’s degree in Biological Sciences, Molecular Biology, Biochemistry, or a related field with extensive and demonstrated track record of experience in conducting oncology research in an academic or industry setting.

Please submit your resume to our network at  (please apply to the Research Scientist – Discovery Biosciences, Oncology (Onsite – Cambridge, MA) role).

Please feel free to forward this project opening to others who may be interested.

Stage 4 Solutions is an equal-opportunity employer. We celebrate diversity and are committed to providing employees with an inclusive environment that is free of discrimination and harassment. All employment decisions are based on the job requirements and candidates’ qualifications, without regard to race, color, religion/belief, national origin, gender identity, age, disability, marital status, genetic information, or other applicable legally protected characteristics.

Compensation: $45/hr.

- $50.91/hr.