Senior Scientist, Viral Vectors

Job Function:

Discovery & Pre-Clinical/Clinical Development

Biological Research

Scientific/Technology

Cambridge, Massachusetts, United States of America

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

We are seeking a highly motivated and experienced scientist to join our CAR-T cell therapy discovery efforts as a Senior Scientist. In this role, you will play a key part in advancing our research initiatives by leveraging your expertise in viral vectors and molecular biology.

This position presents a unique opportunity to contribute to groundbreaking research in CAR-T cell therapy. If you are passionate about advancing scientific discovery and possess a collaborative mindset, we invite you to apply!

• Utilize your extensive knowledge in vector generation & testing, virology, and molecular biology to contribute meaningfully to our cell therapy platform and pipeline development.
• Conduct viral vector screening, optimize vector packaging and production, and perform analytical quantification of viral vector particles using relevant assessments including protein and PCR-based assays, particle potency testing via flow cytometry, and vector copy number (VCN) analysis.
• Play a key role in the development of innovative vector analytical and characterization assays.
• Leverage your familiarity with automation platforms to scale viral vector production, analytical testing, and cell-based activity measurements.
• Contribute to optimization efforts focused on increasing viral titers and purity to enhance the overall efficiency of production processes.
• Collaborate closely with cross-functional teams to test viral vector designs, ensuring the delivery of reliable and consistent data. Present data to research and cross-functional teams.
• Stay informed about industry developments, continuously learn, and thrive in a fast-paced team environment.
• Deliver results in alignment with project timelines while maintaining accountability for your work.
• Ensure compliance with Good Laboratory Practices (GLP) and Environmental Health and Safety (EHS) protocols.

• Ph.D. in a relevant field (e.g. Pharmaceutical Science, Molecular Biology, Biochemistry, Biotechnology, etc.) with 1-2 years of relevant experience OR a Master’s or Bachelor’s degree with extensive experience.
• Significant experience in enveloped viruses and viral vector production, analytical testing, and characterization. Experience with lentiviral vectors required.
• Experience with high throughput assays, techniques, and workflows preferred.
• Demonstrated rigor in assay development and data analysis.
• Strong knowledge of molecular/cell biology techniques, cell culture, and flow cytometry.
• Highly organized and meticulous, with the ability to handle and pursue multiple projects in parallel with a high degree of autonomy.
• Exceptional analytical and problem-solving skills to develop creative, innovative solutions and meet project objectives.
• Strong collaboration skills and ability to operate effectively within a team environment.
• Experience in maintaining accurate and detailed records of experimental procedures, data, and results in a well-organized electronic lab notebook to ensure reproducibility and accessibility for team members.
• Excellent presentation, verbal communication, and scientific/technical writing skills.

• Accelerating
• Analytical Reasoning
• Clinical Data Management
• Critical Thinking
• Data Analysis
• Data Reporting
• Data Savvy
• Design of Experiments (DOE)
• Drug Discovery Development
• Issue Escalation
• Molecular Diagnostics
• Pharmaceutical Microbiology
• Product Knowledge
• Research Proposals
• Scientific Research
• Standard Operating Procedure…