Principal Scientist, Immunopeptidomics

Position Overview

Principal Scientist, Immunopeptidomics - Cambridge, Massachusetts, United States

Job Function:
Discovery & Pre-Clinical/Clinical Development

Job Sub Function:
Biological Research

Job Category:
Scientific/Technology

• Lead the development and delivery of immunogenicity assays supporting discovery programs across the Innovative Medicine portfolio.
• Hands‑on assay development, high‑throughput screening, and data generation, while working closely with diverse teams of protein engineers, data scientists, and biologists.
• Leading must‑win immunogenicity projects across biologics, CAR‑T, and peptide therapeutics from early discovery through candidate selection.
• Own the design, implementation, and execution of novel high‑throughput assays; continuously improve methods and workflows to enhance efficiency and quality.
• Translate assay results into clear, decision‑enabling interpretations for program and engineering teams.
• Ensure strong data integrity, documentation, and reproducibility.
• Drive rapid innovation and provide technical leadership, while building strong multi‑functional relationships as a scientific partner.
• Develop and operationalize population‑aware immunogenicity risk assessment strategies, ensuring consistent application across programs and integration within discovery and engineering cycles.

• Education:
  
  PhD in Immunology, Biochemistry, Cellular/Molecular Biology, Bioengineering or a related field is required.
• Experience and Skills (Required): 6+ years of proven biotech or pharmaceutical experience; demonstrated expertise in immunology with hands‑on experience developing, implementing, and interpreting complex immune cell‑based assays; strong cross‑functional communication skills with the ability to translate multi‑dimensional datasets into a decision‑relevant narrative.
• Preferred:
  Hands‑on experience with LC‑MS instrumentation in support of immunopeptidomics workflows; experience developing high‑throughput assay workflows from pilot to scalable routine deployment; hands‑on experience with integrated lab automation systems; familiarity with therapeutic engineering concepts; experience working with in silico tools and integrating computational outputs with experimental data.

Anticipated base pay range: $117,000 to $201,250. Eligible for annual performance bonus. Company‑sponsored benefits include medical, dental, vision, life insurance, short‑ and long‑term disability, business accident insurance, group legal insurance, retirement plan (pension) and savings plan (401(k)). Time‑off benefits include Vacation (120 hours per calendar year), Sick time (40 hours), Holiday pay (13 days), Additional leave options such as Parental Leave, Condolence Leave, Caregiver Leave, Volunteer Leave, Military Spouse Time‑Off.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please contact the company.