Bioinformatician​/Data Scientist​/Computational Biologist focused RNA Therapeutics

The Biologics Research Center (BRC) is looking for a bioinformatician, a data scientist, or a computational biologist to join the Bioinformatics and Biotherapeutics modeling team in Cambridge, US.

Internal job title: Senior Expert I/II, Data Science

Location: Cambridge, MA, onsite

One of the key responsibilities is to provide computational, bioinformatic, and statistical support for research and early discovery of RNA therapeutics and RNA platform innovation. Work in a collaborative and multi‑disciplinary environment, translating project needs into bioinformatics solutions, identifying computational needs, and influencing the design of new state‑of‑the‑art analysis techniques.

• Provide bioinformatics support to xRNA pipeline and technology projects by collecting, analyzing, integrating in‑silico parameters, screening and omics data to draw relevant and innovative conclusions.
• Independently design, plan, execute, and document complex data analysis, then interpret, summarize and report findings to help drive decisions and set priorities.
• Follow latest advances in the field, raise awareness, and influence the introduction of novel state‑of‑the‑art computational techniques.
• Collaborate in a matrix environment, working with scientists and teams in different areas to address projects’ specific needs and quickly adapt to new technologies and changing needs.
• Develop user‑friendly applications to make RNA data accessible to bench scientists for broader and repeated use.
• Communicate data and analyses to a broad scientific audience, technical and non‑technical team members and colleagues.
• Independently identify and lead, or support, the development of innovative bioinformatics solutions in a matrix environment to answer scientific questions with an impact on the development of next‑generation xRNA therapeutics biology and platform.

• PhD in Bioinformatics, Computational Biology, Cheminformatics, or a closely related discipline with a minimum of two years post‑graduate experience, or an MS with a minimum of six years relevant work experience, preferably in industry.
• Demonstrated experience working with next‑generation sequencing data (Illumina short reads and/or Pac Bio/Oxford Nanopore long reads), commonly used analysis tools, and ability to develop new pipelines and workflows based on business needs.
• Strong domain knowledge in molecular biology, computational genomics and transcription gene regulation and/or post‑transcription gene regulation; knowledge and research experience in RNA biology; experience in oligonucleotide therapeutics discovery and/or gene therapy highly desired.
• Development and application of machine learning algorithms for predictive modeling.
• Solid programming skills in Python and R, scientific computing with Unix / high‑performance computing environment, including software development practices such as version control, testing, documentation.
• Strong communication skills (oral and written), ability to multi‑task, and to communicate own results to collaborators with different expertise.
• Experience integrating, analyzing, visualizing data from different omics sources, high‑throughput screening, and troubleshooting critical issues or problems, determining causes and possible solutions.
• Ability to monitor and stay up to date on developments within sequencing and genomics to propose improvements and innovation in current workflows.

• Knowledge in oligonucleotide chemistry and RNA structure modeling.
• Experience in lab automation and data management.

Salary ranges:
Senior Expert I: $126,000–$234,000 USD annually.
Senior Expert II: $138,600–$257,400 USD annually. Final salary determined by relevant skills and experience and reviewed periodically.

Compensation includes a performance‑based cash incentive and, depending on level, eligibility for annual equity awards.

US‑based eligible employees receive a comprehensive benefits package, including health, life and disability benefits, a 401(k) with company contribution and match, and additional benefits. A generous time‑off package includes vacation, personal days, holidays and other…