Principal Scientist, Immunopeptidomics

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

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Job Function:
Discovery & Pre-Clinical/Clinical Development
Job Sub Function:
Biological Research
Job Category:
Scientific/Technology
All Job Posting Locations:
Cambridge, Massachusetts, United States of America
Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

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We are searching for the best talent for a Principal Scientist, Immunopeptidomics to be located in Cambridge, MA.

Purpose: Do you want to use your hard-earned skills and drive to make a difference in the lives of patients? Join the growing Discovery Proteomic Platforms (DPP) group within the Discovery Technologies and Molecular Pharmacology (DTMP) department of Therapeutics Discovery to apply groundbreaking approaches to high-scale proteomic analysis! Be part of a motivated team deploying innovative mass spectrometry technologies to tackle challenges in end-to-end drug discovery and development across a leading multiomics organization.

We work shoulder-to-shoulder across biology, chemistry, and data science to deliver clear, reproducible proteomic readouts that move medicines forward. With your help, we will drive development of medicines for our patients!

Lead the development and delivery of immunogenicity assays supporting discovery programs across the Innovative Medicine portfolio. You will focus on hands-on assay development, high-throughput screening, and data generation, while working closely with diverse teams of protein engineers, data scientists, and biologists.

You will be responsible for:

• Leading must-win immunogenicity projects across biologics, CAR-T, and peptide therapeutics from early discovery through candidate selection.
• Owning the design, implementation, and execution of novel high throughput assays; continuously improving. methods and workflows to enhance efficiency and quality.
• Translating assay results into clear, decision-enabling interpretations for program and engineering teams. Ensuring strong data integrity, documentation, and reproducibility.
• Driving rapid innovation and providing technical leadership, while building strong multi-functional relationships as a scientific partner.
• Developing and operationalizing population-aware immunogenicity risk assessment strategies, ensuring consistent application across programs and integration within discovery and engineering cycles.

Qualifications / Requirements

Education:

• PhD in Immunology, Biochemistry, Cellular/Molecular Biology, Bioengineering or a related field is required.

Experience and Skills:

Required:

• 6+ years of proven biotech or pharmaceutical experience is required.
• Demonstrated expertise in immunology with hands-on experience developing, implementing, and interpreting complex immune cell-based assays is required.
• Strong cross-functional communication skills with the ability to translate multi-dimensional datasets into a decision-relevant narrative is required.

Preferred:

• Hands on experience with LC-MS instrumentation in support of immunopeptidomics workflows is preferred.
• Experience developing high-throughput assay workflows from pilot to scalable routine deployment is preferred.
• Hands-on experience with integrated lab automation systems is preferred.
• Familiarity with therapeutic engineering concepts is desirable.
• Experience working with in silico tools and integrating computational outputs with experimental data is preferred.

The anticipated base pay range for this position is $117,000 to $201,250.

The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation's performance over a calendar/performance year. Bonuses are awarded at the…