Bioinformatician​/Data Scientist​/Computational Biologist focused RNA Therapeutics

The Biologics Research Center (BRC) is looking for a bioinformatician, data scientist, or computational biologist to join the Bioinformatics and Biotherapeutics Modeling team in Cambridge, US. The team collaborates closely with experimental scientists to analyse screening, omics data sets, define and develop data analysis pipelines and tools to support our xRNA programs, and to improve technology platforms in the xRNA space.

• Provide bioinformatics support to xRNA pipeline and technology projects by consistently collecting, analysing, and integrating in-silico parameters, screening, and omics data to draw relevant and innovative conclusions.
• Independently design, plan, execute, and document complex data analysis, then interpret, summarise and report findings to help drive decisions and set priorities.
• Follow latest advances in the field, raise awareness, and influence the introduction of novel and state‑of‑the‑art computational techniques.
• Collaborate in a matrix environment, working with scientists and teams in different areas to address projects’ specific needs and quickly adapt to new technologies and changing needs.
• Develop user‑friendly applications to make RNA data accessible to bench scientists for broader and repeated use.
• Communicate data and analyses to a broad scientific audience, technical and non‑technical team members and colleagues.
• Independently identify and lead, or support, the development of innovative bioinformatics solutions in a matrix environment to answer scientific questions with an impact on the development of the next‑generation xRNA therapeutics biology and platform.

• PhD degree in Bioinformatics, Computational Biology, Cheminformatics, or a closely related discipline, with a minimum of two years of post‑graduate experience; or an MS degree with a minimum of six years of relevant work experience, preferably in industry.
• Demonstrated experience working with next‑generation sequencing data (Illumina short reads and/or Pac Bio/Oxford Nanopore long reads), its commonly used analysis tools, and ability to develop new pipelines and workflows based on business needs.
• Strong domain knowledge in molecular biology, computational genomics, transcription gene regulation and/or post‑transcription gene regulation.
• Knowledge and research experience in RNA biology.
• Experience in oligonucleotide therapeutics discovery and/or gene therapy is highly desired.
• Development and application of machine learning algorithms for predictive modelling.
• Solid skills in programming languages, i.e. Python and R, and scientific computing with Unix / HPC environment, including software development practices such as version control, testing, documentation, etc.
• Strong communication skills (oral and written), ability to multi‑task, and to communicate own results also to collaborators with different expertise.
• Experience in integrating, analysing, visualising data from different
  -omics sources, high‑throughput screening and ability to troubleshoot critical issues or problems, determine causes and possible solutions.
• Ability to monitor and stay up‑to‑date on developments within the field of sequencing and genomics to actively propose improvements and innovation in current workflows.

• Knowledge in oligonucleotide chemistry and RNA structure modelling.
• Experience in lab automation and data management.

The salary for this position is expected to range between $126,000 and $234,000 USD annually for Senior Expert I, and $138,600 and $257,400 USD annually for Senior Expert II. The final salary offered is determined based on factors such as relevant skills and experience, and will be reviewed upon joining Novartis.

US‑based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. Employees are also eligible for a generous time‑off package including vacation, personal days, holidays and other leaves.

EEO Statement:
The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

Accessibility and reasonable accommodations:
The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e‑mail to reasonab or call +1(877)395‑2339 and let us know the nature of your request and your contact information.

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