Principal Scientist I​/II, Molecular Pathology

# Principal Scientist I/II, Molecular Pathology

REQ-Jun 03, 2026

USA### Summary Cambridge, MA (Onsite)    About the Role  The Molecular Pathology team within Oncology Translational Research at Biomedical Research (BR) is seeking a highly motivated Principal Scientist to develop, validate, and scale novel approaches to characterize protein features of drug targets. This onsite role in Cambridge, MA offers the opportunity to work in a highly collaborative laboratory environment alongside cross-functional teams.  

In this role, you will lead efforts to understand how protein features—including proteoforms, localization, conformation, and interactions—impact response and resistance in cancer. You will partner closely with target validation, drug discovery, and translational teams to generate insights from patient samples and translate findings to preclinical models.  Your work will directly contribute to translational strategies across the drug development continuum, from target characterization through biomarker development.###

About the Role###
** Key Responsibilities
*** Contribute to and help shape
** proteomics strategy and technology platforms
** in a translational research environment
* Identify and develop
** novel scientific and methodological opportunities
** based on literature and internal insights
* Design, develop, and scale methods to characterize:  + Proteoforms  + Protein localization  + Conformation  + Protein–protein interactions
* Apply approaches to
** patient-derived samples
** and define translational relevance in
** preclinical models
*** Collaborate across matrixed teams spanning
** Oncology Research, Discovery, and Translational Science
*** Lead or contribute to cross-functional initiatives supporting
** target understanding and biomarker development**###
** Essential Requirements
*** PhD in
** Oncology, Cell Biology, Biochemistry, Molecular Biology**, or a related discipline
* ** Leveling criteria (dual posting):**  +
** Principal Scientist I**: 3+ years of postdoctoral training  +
** Principal Scientist II**:
Postdoctoral training + 3+ years of industry experience
* Proven ability to generate data that
** influences scientific and technical decision-making
*** Experience with:  + In vitro and in vivo models  + Clinical or post-mortem patient samples
* Strong expertise in protein characterization techniques, including:  + Western blotting  + ELISA  + FACS  + High-content imaging  + Microscopy-based approaches
* Experience with methods to
** probe, label, and enrich proteoforms
** or related protein features
* Strong critical thinking, communication, and collaboration skills
* Curiosity and adaptability to explore
** emerging technologies and scientific innovations**###
** Desirable Qualifications
*** Experience with
** mass spectrometry and proteomics workflows** (data generation and interpretation)
* Data analysis and visualization skills (e.g.,
** Spotfire, R**)
** Novartis Compensation and Benefit

Summary:

** The salary for this position is expected to range between $ -  USD Annual per year.

The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the publishedsalary range based on company and market factors.

Your compensation will include a performance-based cash incentive and, depending on the level of therole, eligibility to be considered for annual equity awards.

US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days,holidays and other leaves.
** Why Novartis:
** Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together?
** Benefits and Rewards:
** Learn about all the ways…