Senior Scientist , Pipeline Development & SAR Optimization

Company Description

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address medical challenges tomorrow. We strive to have a remarkable impact on people’s lives across key therapeutic areas – immunology, oncology, neuroscience, and eye care – and through our Allergan Aesthetics portfolio.

We are looking for a Senior Scientist I to join our siRNA group within the Biotherapeutics and Genetic Medicine (BGM) department. The role involves designing and executing innovative experimental approaches to address key scientific challenges in oligonucleotide therapeutics, driving scientific innovation, and collaborating across functions to support the development of novel RNA‑based therapies.

• Lead research efforts within a cross‑functional team to advance new therapeutic targets for siRNA‑based pipeline development.
• Design and execute in vitro and in vivo proof‑of‑concept studies to evaluate siRNA libraries and characterize lead compounds for target engagement and therapeutic benefit.
• Conduct structure‑activity‑relationship (SAR) studies for lead optimization, including siRNA sequence, chemical modification patterns, conjugation sites, and linkers.
• Provide scientific leadership and expertise in candidate nomination and pipeline development.
• Work independently and maintain a high level of productivity and scientific rigor in the laboratory.
• Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experimental directions.
• Collaborate and effectively communicate results with key stakeholders and cross‑functional teams throughout the organization.
• Contribute as a primary author to scientific publications, presentations, and patent applications.
• Mentor and support junior scientists within the team.

• BS, MS, or PhD in chemistry, molecular biology, biochemistry, or related field. Typical experience: >10 years (BS), >8 years (MS), or 0‑3 years (PhD).
• Demonstrated expertise in siRNA therapeutics, including library design, screening, and SAR characterization.
• Proof of experience in siRNA candidate nomination and pipeline development.
• Hands‑on experience with molecular and RNA biology techniques—cell culture, RNA extraction and quantification (RT‑PCR, qPCR, ddPCR), next‑generation sequencing library preparation, protein assays (ELISA, Western blot, JESS), flow cytometry, and other biomarker quantification.
• Experience in assay development and high‑throughput screening for siRNA target identification, validation, mechanism of action studies, biodistribution, and biomarker analysis is a plus.
• Strong understanding of extra‑hepatic delivery of siRNA is highly desirable.
• Proven ability to develop, troubleshoot, and refine assays to enhance sensitivity, reproducibility, and throughput.
• High self‑motivation and capacity to thrive in a fast‑paced, collaborative team environment.
• Strong written and verbal communication skills, with experience in technical reports, publications, or regulatory documentation.

• Comprehensive benefits package including paid time off (vacation, holidays, sick), medical/dental/vision insurance, and a 401(k) plan.
• Eligibility to participate in short‑term incentive programs.

We offer a collaborative work environment, opportunities for professional growth, and the ability to make an impact on the future of healthcare. Join us and be part of a team that is transforming the landscape of genetic medicine.

Abb Vie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer / Veterans / Disabled.

US & Puerto Rico only. For more information, visit equal‑employment‑opportunity‑employer or reasonable accommodations.