Principal Scientist, Analytical Development Cambridge - MA - US R1603014 Posted

Position: Principal Scientist, Analytical Development Cambridge - MA - US R1603014 Posted a day ago
## Principal Scientist, Analytical Development Cambridge - MA - USFind out how well you match with this job
** Working with Us
** Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it.

You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:
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* Position Summary:

** Bristol Myers Squibb (BMS) is looking for an experienced Senior or Principal Scientist specializing in Analytical Development. The ideal candidate will play a pivotal role in advancing analytical methods to support the development and manufacturing of innovative RNA therapeutics. Key responsibilities will center on the utilization of chromatography and mass spectrometry for method development, with a focus on creating and implementing assays to characterize both RNA drug substance and lipid nanoparticle (LNP) drug products.
** Responsibilities:
*** Serve as a subject matter expert in separation science, developing novel analytical methods to characterize RNA-based products and their delivery systems.
* Investigate new techniques and technologies to provide analytical support for research and development activities across different stages of product development.
* Establish methods to identify and characterize impurities related to LNP drug products and assess critical quality attributes of protein-conjugated LNPs.
* Participate in the transfer of methods to internal and external testing laboratories as necessary, providing expertise and documentation—including standard operating procedures (SOPs), technical reports, and method qualification plans—to facilitate method verification, qualification, and validation.
* Collaborate with internal teams, including RNA Process Development (PD), LNP PD, research, and preclinical manufacturing, as well as broader BMS groups, to meet program timelines and support routine testing requirements.
* Lead troubleshooting efforts and provide guidance when analytical challenges arise.
* Supervise routine analytical testing, review data, and perform testing as needed.
* Operate and maintain essential instruments such as high-performance liquid chromatography (HPLC) and mass spectrometry.
* Document and communicate results effectively to team members and leadership.
* Approach analytical challenges with creativity, contributing to the development of a cutting-edge analytical platform.
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* Qualifications:

*** Ph.D. in Analytical Chemistry, Biochemistry, or a related discipline with at least eight years of Chemistry, Manufacturing, and Controls (CMC) experience. Candidates with a B.S. or M.S. and relevant experience will also be considered.
* Extensive experience analyzing various sample types using chromatography (HPLC/UPLC) across different separation modes, including reversed phase, ion exchange, size exclusion, and asymmetric flow field-flow fractionation. Proficiency in associated detection methods such as mass spectrometry (MS), multi-angle light scattering (MALS), and charged aerosol detection (CAD) is required.
* Hands-on expertise in method development and impurity characterization for LNP-related impurities using various detection techniques is highly desirable.
* Experience with RNA/oligonucleotides, lipid nanoparticles, and/or proteomics is strongly preferred.
* Familiarity with Good Practice (GxP) principles for development, documentation, and qualification is preferred.
* Experience with early-stage product development is advantageous.
* Demonstrated problem-solving…