Senior Scientist, Proteomics

Senior Scientist, Proteomics

Expedition is seeking a motivated and innovative Senior Scientist, Proteomics to join our team. In this role, you will play a critical role in the development and application of cutting‑edge chemoproteomics workflows to support drug discovery programs and platform innovation. The successful candidate will combine strong experimental expertise in mass spectrometry‑based proteomics with quantitative data analysis skills to enable biological insight and drive decision‑making across multidisciplinary discovery teams.

• Operate, maintain, and troubleshoot state‑of‑the‑art LC‑MS instrumentation, including Orbitrap Tribrid platforms with FAIMS
• Develop, optimize, and execute targeted chemoproteomics workflows to support discovery programs
• Design and improve scalable sample preparation and experimental workflows for high‑throughput proteomics applications
• Analyze and interpret large‑scale proteomics datasets using quantitative and statistical approaches
• Collaborate closely with proteomics, biology, chemistry, and computational teams to design experiments, interpret results, and guide project strategy
• Develop and implement innovative chemical proteomics technologies and methodologies to enhance platform capabilities
• Communicate findings and technical advances clearly across cross‑functional teams

• Ph.D. in analytical chemistry, chemical biology, biochemistry, or a related discipline with 4+ years of industry experience, or M.S. degree with 6+ years of industry experience
• Extensive hands‑on experience with mass spectrometry‑based proteomics workflows and instrumentation
• Experience with quantitative proteomics methods including TMT, DIA, PRM, or related approaches
• Experience with targeted chemoproteomics workflows and applications
• Experience with peptide mapping and/or intact mass spectrometry is preferred
• Proficiency in analyzing complex, large‑scale proteomics datasets using computational methods and programming languages such as Python or R
• Expert level understanding of proteomics data analysis software (e.g., MSFragger, Proteome Discoverer, Spectronaut, Max Quant)
• Strong understanding of experimental design, assay optimization, reproducibility, and quantitative data interpretation
• Experience with laboratory automation platforms (e.g., Hamilton, Agilent Bravo) is a plus
• Excellent communication and cross‑functional collaboration skills
• Demonstrated ability to work independently and manage multiple priorities in a fast‑paced environment

Cambridge, MA

Salary range for this role is $126,000 - $159,500. Compensation will depend on qualifications, skills, and experience. Benefits include healthcare coverage, annual incentive program, retirement benefits, and other benefits.

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.