Senior Scientist , siRNA Pipeline Development & Targeted Delivery

Job Description

At Abb Vie, we are dedicated to solving some of the world’s most complex and serious diseases. Our mission is to develop and deliver advanced therapeutics that change lives. We are looking for talented, passionate, and driven individuals to join our Biotherapeutics and Genetic Medicine (BGM) team. As a Senior Scientist in our siRNA group, you will be part of an innovative team focused on advancing RNA-based therapies that have the potential to revolutionize patient care.

Abb Vie is looking for a Senior Scientist I to join our siRNA group within the Biotherapeutics and Genetic Medicine (BGM) department. This role will involve designing and executing innovative experimental approaches to address key scientific challenges related to oligonucleotide therapeutics. The successful candidate will drive scientific innovation, identify new methods and techniques, and collaborate across functions to support the development of novel RNA-based therapies.

• Lead research efforts within a cross‑functional team to advance new therapeutic targets for siRNA‑based pipeline development.
• Design and execute in vitro and in vivo proof‑of‑concept studies to evaluate novel extrahepatic, targeted siRNA delivery platforms across multiple pipeline programs.
• Design and execute receptor expression profiling, ligand–receptor binding, internalization, and trafficking assays.
• Evaluate functional delivery and target knockdown in receptor‑positive cells and tissues.
• Provide scientific leadership and expertise in candidate nomination and pipeline development.
• Work independently and maintain a high level of productivity in the laboratory, ensuring efficiency and scientific rigor.
• Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experimental directions.
• Collaborate and effectively communicate results with key stakeholders and cross‑functional teams throughout the organization.
• Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications.
• Mentor and support junior scientists within the team.

• BS, MS, or PhD in chemistry, biology, biochemistry, pharmacology, or related field with typically 10+ years (BS), 8+ years (MS), or 0–3 years (PhD) of experience.
• Demonstrated expertise in siRNA candidate nomination and pipeline development.
• Demonstrated experience in drug delivery platforms, receptor biology and targeted delivery.
• Hands‑on experience of uptake, trafficking, and functional delivery assays.
• Extensive hands‑on experience and techniques for molecular and RNA biology, including cell culture, RNA extraction, RNA quantification (RT‑PCR, qPCR, ddPCR), next‑generation sequencing (NGS) library preparation, protein assays (ELISA, Western blot, JESS), flow cytometry and other biomarker quantification.
• Experience in assay development and high‑throughput screening for siRNA target identification and validation, mechanism of action studies, biodistribution and biomarker analysis is a plus.
• Proven ability to develop, troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput.
• Highly self‑motivated and capable of thriving in a fast‑paced, collaborative team environment.
• Strong written and verbal communication skills, with experience contributing to technical reports, publications, or regulatory documentation.

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k).
• This job is eligible to participate in our short‑term incentive programs.

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range.

This range may be modified in the future.

Abb Vie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer / Veterans / Disabled.

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