Senior Scientist , siRNA Pipeline Development & SAR Optimization

Job Description

Abb Vie is looking for a Senior Scientist I in the siRNA group within the Biotherapeutics and Genetic Medicine department. Your work will involve designing and executing innovative experimental approaches to address key scientific challenges related to oligonucleotide therapeutics.

• Lead research efforts within a cross‑functional team to advance new therapeutic targets for siRNA‑based pipeline development.
• Design and execute in vitro and in vivo proof‑of‑concept studies to evaluate siRNA library and characterize lead compounds for target engagement and therapeutic benefits.
• Design and execute structure‑activity‑relationship (SAR) studies for lead optimization, including optimization of siRNA sequence, chemical modification patterns, conjugation sites and linkers.
• Provide scientific leadership and expertise in candidate nomination and pipeline development.
• Work independently and maintain a high level of productivity in the laboratory, ensuring efficiency and scientific rigor.
• Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experimental directions.
• Collaborate and effectively communicate results with key stakeholders and cross‑functional teams throughout the organization.
• Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications.
• Mentor and support junior scientists within the team.

• BS, MS, or PhD in chemistry, molecular biology, biochemistry, or related field with typically 10+ years (BS), 8+ years (MS), or 0‑3 years (PhD) of experience.
• Demonstrated expertise in siRNA therapeutics, including library design, screening and characterization of SAR.
• Demonstrated expertise in siRNA candidate nomination and pipeline development.
• Extensive hands‑on experience and techniques for molecular and RNA biology, including cell culture, RNA extraction, RNA quantification (RT‑PCR, qPCR, ddPCR), NGS library preparation, protein assays (ELISA, Western blot, JESS), flow cytometry and other biomarker quantification.
• Experience in assay development and high‑throughput screening for siRNA target identification and validation, mechanism of action studies, biodistribution and biomarker analysis is a plus.
• Strong understanding of ex‑hepatic delivery of siRNA is highly desirable.
• Proven ability to develop, troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput.
• Highly self‑motivated and capable of thriving in a fast‑paced, collaborative team environment.
• Strong written and verbal communication skills, with experience contributing to technical reports, publications, or regulatory documentation.

• Compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range.
  
  This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short‑term incentive programs.

Abb Vie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.