Principal Scientist, Spatial Omics

Principal Scientist, Spatial Omics

Location:

Cambridge, MA or Spring House, PA

The ideal candidate will lead the development, validation, and deployment of cutting‑edge spatial and molecular profiling capabilities to advance therapeutic discovery across neuroscience, oncology, and immunology.

• Lead the development, optimization, and validation of spatial genomics and molecular profiling assays to support neuroscience, oncology, and immunology programs.
• Design and execute experimental workflows involving tissue processing, immunohistochemistry, in situ hybridization, microscopy, high‑resolution slide imaging and sequencing. Experience with Bruker Cos Mx and 10x Genomics Visium is highly preferred and will be required for this role.
• Establish and refine new molecular assays, including troubleshooting, workflow development, and technical feasibility assessments.
• Build and scale laboratory infrastructure, including lab setup, instrumentation planning, and operational readiness.
• Manage CROs and external partners, ensuring high‑quality data generation, timeline alignment, and technical deliverables.
• Collaborate closely with therapeutic area teams to translate multiomics and spatial readouts into actionable biological insights.
• Contribute to data workflows by supporting early‑stage data mapping, QC frameworks, and analytical handoffs to computational teams.

• Education:
  
  Minimum of a PhD in Genetics, Genomics, Molecular Biology, Molecular Pathology, Systems biology, Human biology or a related discipline (post‑doctoral fellowship or equivalent industry experience may be considered).
• A minimum of 6 years of biotech or pharmaceutical industry experience (academic staff scientist experience in deeply technical, matrixed, project‑facing roles may be considered).
• Strong track record of high‑impact scientific deliverables as evidenced by publications, presentations, and recognition within the scientific community.
• Deep, technical spatial omics expertise, including understanding of end‑to‑end workflows, method limitations, and mitigation strategies.
• Excellent written, verbal, and oral presentation skills.
• Experience with multi‑omic datasets.
• Demonstrated ability to work across disciplines and functional areas.
• Proficiency in programming languages such as R or Python (preferred).
• In vitro cell culture and genomics library design experience (preferred).
• Experience as a problem solver, and team collaborator able to facilitate understanding between biologists and data scientists (preferred).
• Ability to manage multiple projects and meet deadlines (preferred).
• Experience working with and/or guiding external collaborators in industry or academia (preferred).

$117,000 to $201,250 per year, with eligibility for annual performance bonus.

• Health, dental, vision, life insurance, short‑term and long‑term disability.
• Retirement plan (401(k) with company matching).
• Long‑term incentive program.
• Paid time off, sick leave, holiday pay, parental leave.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you have a disability and would like to request an accommodation, please contact us via  or contact AskGS to be directed to your accommodation resource.