Scientist, Oncology Bioinformatics

Overview

The role will support Moderna’s oncology pipeline by contributing computational analyses across research and preclinical development. You will work at the intersection of antigen discovery, tumor immunology, and multi-omics data analysis, applying established and emerging computational approaches to help characterize tumor biology and immune responses. In this highly collaborative environment, you will partner closely with oncologists, immunologists, biologists, and platform technology teams to generate insights that inform target discovery and early-stage therapeutic development for mRNA-based cancer vaccines and immunotherapies.

• Analyze and integrate multi-omics datasets (e.g., WES/WGS, RNA-seq, single-cell) to characterize tumor antigen landscapes
• Apply computational methods to support antigen discovery efforts and investigate tumor-immune interactions and underlying mechanisms
• Leverage internal and public datasets (e.g., TCGA, GTEx, IEDB) for biomarker exploration and hypothesis generation
• Develop and maintain reproducible analysis workflows using Python, R, and cloud-based infrastructure (e.g., AWS)
• Collaborate with cross-functional teams in immunology, oncology, and translational research to support experimental design and data interpretation
• Communicate results clearly through presentations, summaries, and documentation to support team decision-making

• Ph.D., or M.S. with 4+ years of experience, in Bioinformatics, Computational Biology, or a related field
• Experience with high-throughput sequencing data analysis, including DNA-seq and RNA-seq
• Proficiency in Python and/or R for data analysis
• Experience working in cloud environments (e.g., AWS)
• Demonstrated ability to apply computational approaches to biological or early-stage translational research problems
• This position is site-based, requiring you to be at Moderna’s site full-time. This position is not eligible for remote work

• Exposure to immuno-oncology, cancer vaccines, tumor immunology, or computational immunology
• Familiarity with neoantigen prediction approaches, including HLA typing and peptide-MHC binding tools (e.g., NetMHCpan)
• Experience with immunogenomics resources (e.g., IEDB, TCGA)
• Strong collaboration and communication skills in a team-oriented environment

At Moderna, we believe that when you feel your best, you can do your best work. That’s why our US benefits and global well-being resources are designed to support you—at work, at home, and everywhere in between.

• Best-in-class healthcare coverage, plus voluntary benefit programs to support your unique needs
• A holistic approach to well-being, with access to fitness, mindfulness, and mental health support
• Family planning benefits, including fertility, adoption, and surrogacy support
• Generous paid time off, including vacation, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdown
• Savings and investment opportunities to help you plan for the future
• Location-specific perks and extras

The salary range for this role is $ - $. This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An individual’s position within the salary range will be based on several factors including, but not limited to, specific competencies, relevant education, qualifications, certifications, experience, skills, performance, and business or organizational needs.

The successful candidate may be eligible for an annual discretionary bonus, other incentive compensation, or equity award, subject to company plan eligibility criteria and individual performance.

Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world.

By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an…