Senior Scientist II, Brain Transport Biology

Job Description

At Abb Vie, we are dedicated to solving some of the world’s most complex and serious diseases. Our mission is to develop and deliver advanced therapeutics that change lives. The Discovery Neuroscience In Vivo Pharmacology group in Cambridge, Massachusetts, is seeking a highly skilled and self‑motivated Senior Scientist to support target identification, validation, and drug transport facilitation across brain barriers. The successful candidate will drive scientific innovation, make tangible contributions to the discovery pipeline, and have people and project‑management experience.

• Design and implement in vivo testing of multispecific biologics, small molecules, and siRNAs to support projects in Alzheimer’s and Parkinson’s disease.
• Serve as an in vivo representative in cross‑functional teams with Discovery Biotherapeutics, DMPK, and Development Sciences, providing project updates, analysis, and strategic advice.
• Translate department – project team scientific questions into well‑designed experiments using internal and external resources.
• Identify and solve technical problems independently; implement new assays and workflows; conceive and implement innovative research ideas.
• Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experimental directions.
• Collaborate with cross‑functional partners at various Abb Vie sites to advance candidates through discovery milestones.
• Work independently and maintain a high level of productivity in the laboratory, ensuring efficiency and scientific rigor.
• Mentor / matrix‑manage junior scientists and be accountable for the effective performance of the team.
• Ensure consistency and quality of technical reports.
• Uphold impeccable research‑related and corporate compliance standards.
• Authored or co‑author peer‑reviewed scientific papers or patents.

• Bachelor’s degree with typically 12 years of experience;
  Master’s degree with typically 10 years of experience;
  PhD with typically 4 years of experience.
• Background in receptor and/or transporter biology and targeted delivery.
• Background in brain barrier biology.
• Experience with in vivo models of neurodegeneration, particularly Alzheimer’s and Parkinson’s disease.
• Experience in assay development for target identification and validation, mechanism of action studies, biodistribution, and biomarker analysis; proven ability to troubleshoot and refine assays and workflows.
• Proven track record in characterizing complex biotherapeutics in vivo (biologics, small molecules, siRNA).
• Proven track record of working in multidisciplinary in vivo pharmacology teams, collaborating effectively in a dynamic, cross‑functional matrix environment.
• Experience managing direct reports, providing performance evaluations and development opportunities.
• Excellent organizational skills, strong data analysis and critical thinking skills, and the ability to manage multiple projects simultaneously.
• Goal‑oriented, self‑motivated team player with excellent verbal and written communication skills, contributing to technical reports and publications.

• Experience operating effectively in a matrixed, fast‑paced discovery organization.
• Experience in managing external collaborations.
• Experience with ex vivo readouts, including immunohistochemistry and biochemistry (e.g., ELISA, WB, qPCR, ddPCR), and image analysis.
• Familiarity with CNS‑relevant biology and genetic medicine applications.

• Compensation:
  The compensation range described below represents the range of base pay compensation that the Company believes in good faith it will pay for this role at the time of posting based on the job grade. Individual compensation within this range will depend on factors such as geographic location; the Company may ultimately pay more or less than the posted range, which may be modified in the future.
• Benefits package includes paid time off (vacation, holidays, sick), medical/dental/vision insurance and a 401(k) plan for eligible employees.
• This position is eligible to participate in long‑term incentive programs.

Note:

No amount of pay is considered wages or compensation until it is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or other compensation remain at the Company’s sole and absolute discretion until paid and may be modified at the Company’s discretion, consistent with applicable law.

Abb Vie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.
Equal Opportunity Employer / Veterans / Disabled.

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