Oligo Discovery Chemistry Principal Scientist

Location:

USA
- Massachusetts
- Cambridge
Posted Date:
May 1 2026

• Establish pre‑clinical oligonucleotide mid‑scale synthesis capabilities of ASOs, siRNA, SSO, and RNA editors with routine and novel next generation amidite chemistries.
• Develop and maintain discovery mid‑scale workflows.
• Perform hands‑on work, establish oligo synthesis workflows and draft SOPs in support of next generation chemistry and method development.
• Serve as the mid‑scale oligo synthesis SME for the team, representing oligo synthesis in various cross‑matrix meetings.
• Develop and maintain standard operating procedures (SOPs) for synthesis, processing, and purification to ensure high‑quality, reproducible results.
• Work with the oligo analytical and conjugate chemistry teams to ensure accountability and excellence in oligonucleotide and conjugate synthesis.
• Collaborate and communicate across various teams to build robust workflows, or leverage internal resources to deliver on portfolio endpoints.

• PhD with 3+ years’ experience in chemistry, oligonucleotide synthesis, or chemical biology or related fields.
• 2+ years of industry experience in modern synthetic chemistry methods, particularly nucleosides, nucleotides, and oligonucleotide synthesis, purification, and analysis.
• General familiarity with mid‑scale synthesizers, such as ÄKTA Oligosynt synthesizers, Cytiva, ÄKTA Avant and Pure purification systems with Unicorn software, and LC/HRMS, UPHLC, LC/MS analytics.
• Expertise in oligonucleotide synthesis (SPOS), and biological familiarity of RNA therapeutics (e.g. ASO, siRNA, SSO, RNA Editors).
• Team‑focused with strong initiative and experience troubleshooting challenges and implementing new solutions.
• Prior experience with scientific and professional mentorship and project leadership.

• Excellent written and verbal communication skills, attention to detail, organizational skills, and the ability to collaborate effectively with a team are required.
• Experience with oligonucleotide conjugation chemistries is desirable but not required.
• Demonstrable sense of urgency, flexibility, independence and accountability.
• Demonstrated ability to maintain a high level of integrity while balancing multiple priorities and responsibilities.
• Must be a committed team player prepared to work in and embrace a team‑based culture.

This role is full‑time on‑site at our Cambridge MA offices.

We value curiosity, accountability, and respectful collaboration. We look for practical problem solvers who communicate clearly and act with scientific rigor. We welcome people with varied backgrounds and perspectives who will strengthen our inclusive team.

Location‑based annual base salary ranges from $121,275 to $202,125. The US salary ranges take into account a number of factors including work location within the US market, the candidate's skills, experience, education level and the market rate for the role. This position offers an annual bonus and eligibility to participate in a share‑based long‑term incentive program. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

If you are excited about this opportunity, please submit your CV and a short note describing what motivates you about this role. We look forward to learning how your skills and experience can help us get ahead of disease together.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

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