Senior Scientist, Vector Biology

Senior Scientist, Vector Biology

Location:

Cambridge, Massachusetts, United States of America

Discovery & Pre-Clinical/Clinical Development

Biological Research

Scientific/Technology

We are seeking a highly motivated and experienced scientist to join our CAR‑T cell therapy discovery efforts as a Senior Scientist. In this role, you will play a key part in advancing our research initiatives by leveraging your expertise in viral vectors and molecular biology.

This position presents a unique opportunity to contribute to groundbreaking research in CAR‑T cell therapy. If you are passionate about advancing scientific discovery and possess a collaborative mindset, we invite you to apply!

• Design, modify, optimize, and screen viral envelopes/proteins to target delivery to specific cell types of interest.
• Apply virology, molecular biology, cell biology, and biochemistry methods to establish rigorous experimental workflows and protocols for optimizing and analyzing design outcomes.
• Support the development of innovative vector analytical and characterization assays.
• Contribute to optimization efforts focused on increasing viral titer, potency, and purity to enhance the overall efficiency of production processes.
• Apply your extensive knowledge in vector design, virology, and molecular biology to contribute meaningfully to our cell therapy platform and pipeline development.
• Collaborate closely with cross‑functional teams to test viral vector designs, ensuring reliable and consistent data, and present data to research and cross‑functional teams.
• Stay informed about industry developments, continuously learn, and thrive in a fast‑paced team environment.
• Deliver results in alignment with project timelines while maintaining accountability for your work.
• Ensure compliance with Good Laboratory Practices (GLP) and Environmental Health and Safety (EHS) protocols.

• Ph.D. in a relevant field (e.g. Pharmaceutical Science, Molecular Biology, Biochemistry, Biotechnology, etc.) with 1–2 years of relevant experience OR a Master’s or Bachelor’s degree with extensive experience.
• Significant hands‑on experience in enveloped viruses and viral vector engineering, including production and characterization.
• Demonstrated experience engineering, testing, and optimizing pseudotyped lentiviral vectors is strongly preferred.
• Strong knowledge of molecular and cell biology techniques, such as cell culture of various cell types, and flow cytometry, qPCR, immunofluorescence, and protein‑based methods (Western blot, ELISA).
• Experience with high‑throughput assays, techniques, and workflows is preferred.
• Highly organized and meticulous, with the ability to handle and pursue multiple projects in parallel with a high degree of autonomy.
• Exceptional analytical and problem‑solving skills to develop creative, innovative solutions and meet project objectives.
• Strong collaboration skills and the ability to operate effectively within a team environment.
• Experience in maintaining accurate and detailed records of experimental procedures, data, and results in a well‑organized electronic lab notebook to ensure reproducibility and accessibility for team members.
• Excellent presentation, verbal communication, and scientific/technical writing skills.

• Accelerating
• Analytical Reasoning
• Clinical Data Management
• Critical Thinking
• Data Analysis
• Data Reporting
• Data Savvy
• Design of Experiments (DOE)
• Drug Discovery Development
• Issue Escalation
• Molecular Diagnostics
• Pharmaceutical Microbiology
• Product Knowledge
• Research Proposals
• Scientific Research
• Standard Operating Procedure (SOP)
• Technologically Savvy

Anticipated base pay range: $ – $.

Subject to the terms of the company’s consolidated retirement plan and 401(k).

• Vacation – 120 hours per calendar year
• Sick time – 40 hours per calendar year (48 hours in Colorado, 56 hours in Washington)
• Holiday pay, including floating holidays – 13 days per calendar year
• Work, Personal and Family Time – up to 40 hours per calendar year
• Parental Leave – 480 hours within one year of birth/adoption/foster care of a child
• Bereavement Leave – 240 hours for an immediate…