Postdoctoral Fellow – Human Genetics & Cardiometabolic Disease

Career Category Postdoctoral Job Description

In this vital role, you will advance our understanding of the genetic and biological mechanisms underlying cardiovascular and cardiometabolic disease through the application of human genetics, functional genomics, and computational biology. Working within Amgen Research, you will leverage large-scale human genetic datasets and emerging genomic technologies to identify novel disease pathways and therapeutic opportunities. This position is ideal for a highly motivated scientist interested in translating genetic discoveries into biological insights.

The successful candidate will work at the intersection of human genetics, data science, and disease biology, integrating diverse genomic and molecular datasets to investigate the functional consequences of genetic variation and uncover mechanisms that influence human health and disease.

• Analyze and integrate large-scale human genetic datasets to identify genes, pathways, and biological mechanisms associated with cardiovascular and cardiometabolic traits.
• Apply computational and statistical approaches to investigate the functional consequences of genetic variation across diverse populations.
• Utilize functional genomics, single‑cell technologies, and systems biology approaches to understand how genetic variation influences cellular and molecular processes.
• Integrate multiple layers of genomic and molecular data to prioritize therapeutic hypotheses and uncover disease‑relevant regulatory networks.
• Develop and apply innovative analytical approaches to connect human genetic findings with disease biology.
• Collaborate with multidisciplinary teams spanning genetics, computational biology, molecular biology, and therapeutic discovery.
• Present research findings at internal and external scientific meetings and publish results in high-impact peer-reviewed journals.
• Contribute to the broader scientific mission of translating human genetic insights into novel therapeutic strategies.

• Doctorate degree (PhD) completed prior to the start date from an accredited college or university in Human Genetics, Statistical Genetics, Computational Biology, Bioinformatics, Genomics, Biomedical Sciences, Molecular Biology, or a related scientific discipline.

• Strong record of scientific achievement as demonstrated through peer-reviewed publications and presentations.
• Experience working with large-scale human genetic datasets, including genome-wide association studies, sequencing studies, population biobanks, or related resources.
• Expertise in computational analysis of genomic, transcriptomic, proteomic, or other multiomic datasets.
• Familiarity with statistical genetics, functional genomics, systems biology, or gene regulatory network analysis.
• Experience with single-cell genomic technologies and integrative data analysis approaches.
• Proficiency in computational programming and data analysis using tools such as Python, R, or similar languages.
• Demonstrated ability to develop innovative approaches to address complex biological questions.
• Strong written and verbal communication skills.
• Ability to work effectively in a collaborative, multidisciplinary research environment.
• Passion for scientific discovery and a strong interest in translating human genetic findings into biological and therapeutic insights.

81,178.40

USD–USD