Senior Scientist II Cellular and Spatial Biology

Job Title

Senior Scientist Cellular and Spatial Biology

Cambridge, MA

We are looking for a highly motivated and innovative scientist to join the Target, Disease & Systems Biology (TDSB) department at Sanofi as a Senior Scientist. In this role, you will collaborate across the Pre‑clinical Omics research cluster to investigate disease biology, uncover novel pathways and mechanisms, and identify strategies to address unmet medical needs across a range of therapeutic areas.

The position offers the opportunity to apply cutting‑edge molecular biology and spatial technologies to advance our therapeutic discovery efforts.

• Experimental Design & Execution:
  Design and perform experiments using bulk RNA‑seq, single‑cell/single‑nucleus RNA‑seq (sc/snRNA‑seq), NGS and spatial assays (Geo Mx, Visium, Xenium, Phenocycler‑Fusion) on human and non‑human biological samples. Optimize and troubleshoot protocols for molecular and spatial assays.
• Data Analysis & Interpretation:
  Collaborate with bioinformatics teams to analyze high‑dimensional omics data. Interpret results to guide therapeutic target identification and validation.
• Technology Development & Innovation:
  Evaluate and implement emerging molecular biology and spatial technologies. Contribute to the development of novel workflows and platforms.
• Cross‑functional
  
  Collaboration:
  
  Work closely with scientists across biology, chemistry, and computational disciplines. Present findings in internal meetings and contribute to strategic research discussions. Work with Program teams to represent TDSB and suggest TDSB capabilities to push program support.
• Documentation & Reporting:
  Maintain detailed experimental records. Prepare technical reports and presentations.

• Master’s degree in Molecular Biology, Cellular Biology, Genomics, Neurobiology or related field with 5+ years of post‑master’s experience, or Ph.D. with 3+ years post‑doctoral experience (academic or industry).
• Demonstrated expertise in transcriptomics and spatial biology: scRNA‑seq, snRNA‑seq, bulk RNA‑seq, Next‑Gen Sequencing (NGS).
• Strong problem‑solving skills and ability to work independently and collaboratively.
• Excellent communication and organizational skills.

• Experience with spatial transcriptomics platforms (10x Genomics Visium, Xenium, Nano String Geo Mx).
• Experience with spatial proteomics technologies (Akoya CODEX, Phenocycler‑Fusion).
• Proficiency in tissue handling, imaging, and histological techniques.
• Familiarity with bioinformatics tools and pipelines for omics data analysis.

Competitive salary range of $ – $, based on experience. Health and wellbeing benefits including high‑quality healthcare, prevention and wellness programs, at least 14 weeks’ gender‑neutral parental leave. Additional benefits include a thoughtful rewards package that recognizes contributions and amplifies impact.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and affirmative action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender, gender identity or expression, sexual orientation, disability, veteran or military status or liability for military status, domestic violence victim status, atypical cellular or blood trait, genetic information or any other characteristic protected by law.