Scientist - II; Associate

Scientist II - Histology and Spatial Biology

Cambridge, MA

Pay Rate: $56.66/hr W2

• BS with 6 years or M.Sc. with 4 years or PHD with 2 years in a relevant scientific discipline with significant hands‑on experience in histological techniques.
• Demonstrated expertise in antibody validation using chromogenic and multiplex immunofluorescence staining methods.
• Familiarity with automated staining platforms, preferably the Leica BOND system.
• Strong experience in high‑plex spatial biology and multiplex immunofluorescence methodologies, including platforms such as Lunaphore COMET, CODEX, Cell Scape, and imaging mass cytometry.
• Experience operating microscopy systems and modern slide scanners such as Leica GT450, Akoya Pheno Imager, or Zeiss Axioscan.
• Proficiency with image visualization and analysis software, such as HALO, QuPath, and Image
  
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• Strong scientific judgment, critical thinking, and problem‑solving skills.
• Excellent communication and collaboration skills, with the ability to work effectively across teams.
• Curiosity, adaptability, and a proactive mindset toward learning and implementing new technologies.

• Experience with assay development, optimization, and troubleshooting in a research or translational setting.
• Familiarity with tissue biomarker evaluation, spatial tissue profiling, or pathology‑adjacent workflows.
• Experience documenting and standardizing workflows, SOPs, and QC procedures.
• Ability to independently prioritize requests and manage multiple concurrent projects.
• Demonstrated experience working in a matrixed, interdisciplinary environment.
• Exposure to data interpretation and presentation of histology or imaging‑based results to scientific stakeholders.

We are seeking an experienced scientist with deep, hands‑on expertise in histology and antibody validation to join a fast‑paced and highly collaborative scientific environment. This role will support multiple ongoing spatial omics projects including biomarker discovery and target validation initiatives requiring someone who is highly adaptable, detail‑oriented, and comfortable balancing planned work with urgent, short‑term requests. The ideal candidate thrives in a dynamic environment, approaches shifting priorities as an opportunity, and can deliver high‑quality work across a broad range of histology and multiplex imaging workflows.

• Contribute to and help shapeDAGS multiomics and spatial biology experimental strategies.
• Support the maintenance, troubleshooting, and optimization of histology instruments and associated laboratory workflows. Maintain, calibrate, and document the use of laboratory equipment in compliance with internal standards.
• Perform routine and advanced preparation of histological slides from FFPE blocks, including embedding, sectioning, staining, labeling, and quality assessment.
• Perform antibody validation using chromogenic and multiplex immunofluorescence approaches to support assay development and target validation.
• Design, optimize, and validate multiplex immunofluorescence panels using the Lunaphore COMET platform and execute assigned projects with accuracy and timeliness.
• Collaborate with cross‑functional and cross‑departmental teams to support target evaluation, assay troubleshooting, and technology implementation.
• Manage multiple priorities effectively in a fast‑paced setting while maintaining scientific rigor and attention to detail.
• Contribute ideas for workflow improvements, assay optimization, and adoption of novel technologies.

This 24+ Month Contract Has A Tentitive Start Date of 7/20/2026

JSG offers medical, dental, vision, life insurance options, short‑term disability, 401(k), weekly pay, and more. Johnson Service Group (JSG) is an Equal Opportunity Employer. JSG provides equal employment opportunities to all applicants and employees without regard to race, color, religion, sex, age, sexual orientation, gender identity, national origin, disability, marital status, protected veteran status, or any other characteristic protected by law.