Senior Scientist II Cellular and Spatial Biology

Job Title

Senior Scientist Cellular and Spatial Biology

Cambridge, MA

We are looking for a highly motivated and innovative scientist to join the Target, Disease & Systems Biology (TDSB) department at Sanofi as a Senior Scientist. In this role, you will collaborate across the Pre‑clinical Omics research cluster to investigate disease biology, uncover novel pathways and mechanisms, and identify strategies to address unmet medical needs across a range of therapeutic areas.

This position offers the opportunity to apply cutting‑edge molecular biology and spatial technologies to advance our therapeutic discovery efforts. The ideal candidate will bring strong technical expertise in bulk RNA‑seq, single‑cell/single‑nucleus RNA‑seq (sc/snRNA‑seq), spatial transcriptomics, and spatial proteomics to support a broad scope of research initiatives.

You will lead and execute scientific research, analyze and present complex data, and communicate effectively with both expert and non‑expert audiences. Strong organizational skills—including meticulous record keeping, planning and scheduling, and maintaining laboratory equipment—are essential.

• Design and perform experiments using bulk RNA‑seq, single‑cell/single‑nucleus RNA‑seq (sc/snRNA‑seq), NGS and spatial assays (Geo Mx, Visium, Xenium, Phenocycler‑Fusion) on human and non‑human biological samples.
• Optimize and troubleshoot protocols for molecular and spatial assays.
• Collaborate with bioinformatics teams to analyze high‑dimensional omics data.
• Interpret results to guide therapeutic target identification and validation.
• Evaluate and implement emerging molecular biology and spatial technologies.
• Contribute to the development of novel workflows and platforms.
• Work closely with scientists across biology, chemistry, and computational disciplines.
• Present findings in internal meetings and contribute to strategic research discussions.
• Work with Program teams to represent TDSB and to suggest TDSB capabilities to help push program support.
• Maintain detailed experimental records.
• Prepare technical reports and presentations.

• Master’s degree in Molecular Biology, Cellular Biology, Genomics, Neurobiology or a related field with 5+ years of relevant post‑master’s experience, or Ph.D. in Molecular Biology, Cellular Biology, Genomics, Neurobiology or a related field with 3+ years of post‑doctoral experience (academic or industry).
• Demonstrated expertise in transcriptomics and spatial biology.
• Experience with scRNA‑seq, snRNA‑seq, bulk RNA‑seq, and Next‑Generation Sequencing (NGS).

• Experience with spatial transcriptomics platforms (e.g., 10x Genomics Visium, Xenium, Nano String Geo Mx).
• Experience with spatial proteomics technologies (e.g., Akoya CODEX, Phenocycler‑Fusion).
• Proficiency in tissue handling, imaging, and histological techniques.
• Familiarity with bioinformatics tools and pipelines for omics data analysis.
• Strong problem‑solving skills and ability to work independently and collaboratively.
• Excellent communication and organizational skills.

$ – $ per annum. All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in company employee benefit programs.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Aff
**** ive action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender, gender identity or expression, affectional or sexual orientation, disability, veteran or military status or liability for military status, domestic violence victim status, atypical cellular or blood trait, genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.