Research Investigator, Mass Spectrometry

We are seeking a highly skilled and motivated full time Sr Research Investigator/ Research Investigator. The successful candidate will play a key role in supporting discovery stage programs with a particular focus on targeted protein degradation and next generation biologic therapeutics.

The ideal candidate will possess extensive hands‑on experience in mass spec‑based bioanalysis, protein and peptide characterization, and analytical assay development.

This is a cross‑functional role with significant impact on the research and development pipeline.

• Lead the development, optimization, and fit for purpose validation of LC-MS/MS assays and IP (hybrid ligand binding) assay for quantification of biomarkers, proteins, peptides, cytokines, and metabolites
• Design and execute workflows for peptide mapping, post‑translational modification (PTM) analysis, disulfide bond mapping, and glycosylation analysis
• Develop fit‑for‑purpose bioanalytical methods for proteins with complex attributes (e.g., high MW, high glycosylation, unexpected MWs) using advanced enzymatic digestion strategies
• Determine and communicate goals, timelines, and priorities for bioanalysis in cross‑functional project teams
• Conduct advanced data processing and statistical analysis using multiple software from different vendors
• Maintain and troubleshoot analytical instrumentation
• Maintain technical reports, SOP, and an Electronic notebook

• Minimum of 5 years of relevant industry experience
• Extensive experience with mass spectrometry analysis of proteins and peptides (Sciex QTRAP, Sciex Q-TOF, Thermo Orbitrap Fusion/Lumos, QQQ with MRM method)
• Demonstrated expertise in bioanalytical method development and validation of large molecule analytes
• Experience performing intact and subunit protein mass spectrometry analysis, including characterization of monoclonal antibodies, fusion proteins
• Hands‑on experience with a range of chromatography techniques RP‑HPLC, SEC, HILIC, nanoLC, microLC
• Proficient in wet lab sample preparation techniques (SPE, IP, LLE)
• Ability to maintain and troubleshoot mass spec instrumentation in close collaboration with vendors to ensure optimal system performance and uptime
• Excellent organizational skills and attention to detail
• Ability to balance multitasks with competing priorities
• Strong written and verbal communication skills
• Laboratory‑based position (based in Cambridge)
• Fast paced environment
• Collaboration with cross‑functional R&D and bioanalytical teams

• Experience with computational biology, bioinformatics
• Experience with biochemical, biophysical, biology assays such as SPR, TR‑FRET, ELISA, MSD
• Experience executing method development, validation, and assay transfer at CROs and external partners