Senior Research Associate – Targeted LNP Formulation; Non-Viral Delivery

Role Overview

We are seeking a highly motivated Senior Research Associate to join the Non‑Viral Delivery team to support the development of next‑generation targeted lipid nanoparticle (tLNP) systems for nucleic acid therapeutics. In this role, you will contribute to the design, execution, and optimization of formulation strategies to enable efficient and selective delivery to defined cell types. You will take on increased ownership of experimental workflows, generate high‑quality datasets to guide program decisions, and collaborate closely with cross‑functional teams spanning biology, analytical development, and process sciences.

• Formulation Development & Optimization
  • Develop and optimize targeted lipid nanoparticle formulations for delivery of nucleic acid cargos.
  • Evaluate formulation parameters influencing delivery performance, including composition, ligand density, and process parameters.
  • Support the generation of lipid nanoparticles for in‑vitro and in‑vivo studies, ensuring consistency, quality, and reproducibility.
  • Perform physicochemical, biophysical, and functional characterization of LNPs and conjugates using analytical techniques such as particle sizing (DLS), zeta potential, UV‑Vis and fluorescence spectroscopy, and chromatographic or electrophoretic methods (e.g., HPLC, SDS‑PAGE, LC/MS).
  • Analyze, interpret, and effectively communicate experimental findings through presentations, written reports, and active engagement in scientific discussions and team meetings.
  • Partner closely with teams in biology, immunology, analytical development, and process development to advance programs.
  • Maintain accurate and detailed experimental records while contributing to the improvement of laboratory workflows, robustness, and throughput of formulation and characterization processes.

• B.S. or M.S. in Chemical Engineering, Bioengineering, Pharmaceutical Sciences, Chemistry, Biochemistry, or a related field.
• Typically 2–5+ years of relevant experience in an industry or applied research setting.
• Demonstrated hands‑on experience with design, synthesis, and characterization of nanoparticle formulations in an industry environment.
• Familiarity with targeted delivery approaches, including ligand conjugation and nanoparticle surface functionalization strategies.
• Proficiency in formulation characterization techniques, including dynamic light scattering, zeta potential, UV‑Vis and fluorescence spectroscopy, and chromatographic methods.
• Strong understanding of experimental design and ability to troubleshoot and optimize workflows.
• Exposure to statistical design of experiments (DoE) and data analysis tools.
• Demonstrated ability to work both independently and collaboratively in a team environment.
• Strong organizational skills and attention to detail in data recording and execution.

Cambridge, MA - US: $110,810 - $134,281. The starting compensation range(s) for this role are listed above for a full‑time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. Final, individual compensation will be decided based on demonstrated experience.

• Health Coverage:
  Medical, pharmacy, dental, and vision care.
• Well‑being Support: BMS Well‑Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well‑being and Protection: 401(k) plan, short‑ and long‑term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.

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