Preclinical Safety Profiling Expert, Principal Scientist

About the Role

The Preclinical Safety (PCS) department within the Novartis Biomedical Research Translational Medicine Unit provides world‑class preclinical safety profiling and assessment for optimal drug discovery, development and commercialization, with state‑of‑the‑art regulatory compliance. As a Preclinical Safety Profiling (PSP) Expert, you will join our global PCS team to help us unleash the power of early safety screening and profiling approaches for advancing translational safety assessment and to drive drug discovery and development.

You will bring your curious, innovative, and collaborative mindset to leverage a wealth of non‑clinical safety‑related data generated within our department and deploy state‑of‑the‑art laboratory science and data exploration methods to accelerate the advancement of innovative medicines.

• Design and execute early safety screening & profiling strategies associated with secondary pharmacology and cardiovascular safety, in collaboration with internal and external stakeholders.
• Primary interface between PCS and our CRO partners.
• Manage internal relationships with PSP subject matter experts and the outsourcing resource group, further develop data internalization processes and manage outsourcing budget.
• Effectively communicate with stakeholders, including experimental design, data quality, timeline requirements and flowchart planning.
• Understand and execute agreed business strategy defined by local and global Preclinical Safety Profiling requirements, ensuring appropriate coordination of projects.
• Participate in cross‑functional early safety screening & profiling collaborations with Novartis Biomedical Research partners to support the early derisking of compounds, drug targets, and therapeutic modalities.
• Deliver clear and concise presentations for audiences with different expertise.
• In collaboration with cross‑functional partners, provide scientific and strategic input to support the early derisking of compounds, drug targets, and therapeutic modalities.
• Ensure quality and compliance of data generation, analyses and resultant reports.

• Degree or advanced degree in Pharmacology, Toxicology or a related field.
• 5+ years of relevant experience in pharmacology or toxicology.
• Understands basic concepts of hazard identification and risk assessment associated with drug ADME, off‑target mitigation and cardiovascular safety.
• Familiar with early drug discovery processes.
• Experience with data integrity and quality assurance practices.
• Articulates solutions and recommendations to business users; presents analytical content concisely and effectively and influences outcomes of predictive safety profiling contributions.
• Collaborates with internal stakeholders, external partners, and cross‑functional teams to solve critical business problems, propose operational efficiencies and innovative approaches.
• Familiar with visualization tools to increase efficiency and quality of data communication and interpretation.

This is a dual‑level posting. The final level and title will be determined by the hiring team based on the skills, experience, and capabilities required. Principal Scientist I: $114,100 – $211,900 per year. Principal Scientist II: $119,700 – $222,300 per year. The final salary offered is based on relevant skills and experience and will be reviewed periodically.

US‑based eligible employees receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. Employees are eligible for a generous time‑off package including vacation, personal days, holidays and other leaves.

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If you need a reasonable accommodation for any part of the application process or to perform the essential functions of the position, please email or call  and let us know the nature of your request and your contact information. Please include the job requisition number in your message.